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Extensive sex differences in depression-linked variants functionally assayed in mouse brain [P0&P10]

ABSTRACT: Extensive sex differences in depression-linked variants functionally assayed in mouse brain [P0&P10]

PROVIDER: PRJNA773476 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16525000.fastq.gz	Fastqsanger.gz
	SRR16525001.fastq.gz	Fastqsanger.gz
	SRR16525002.fastq.gz	Fastqsanger.gz
	SRR16525003.fastq.gz	Fastqsanger.gz
	SRR16525004.fastq.gz	Fastqsanger.gz

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Extensive sex differences in depression-linked variants functionally assayed in mouse brain [P0&P10]

Project description:Here, we selected >1000 variants from over 30 depression-associated loci using brain epigenomic data, and functionally assayed them using in vivo functional assays in the mouse brain to examine sex-by-genotype interactions. We identify extensive sex-by-allele effects in mature hippocampus, suggesting genetic risk and thus disease mechanisms may be distinct between the sexes. Unbiased informatics approaches indicated a role for nuclear hormone receptors, which was supported by . Further, comparative analysis of allelic function in the neonatal mouse brain, during a key between developmental neonates during the masculinizing testosterone surge, and in the adult hippocampus—a region of interest in depression pathology—but not at 10 days old, a older hormonally quiescent developmental stage juveniles. Our study provides novel insights into depression genetics as influenced by age, biological sex, and cell type, and provides a framework for in vivo parallel assays at a scale not previously shown possible to functionally define interactions between sex and disease variation.

2023-02-10 | GSE186347 | GEO

Extensive sex differences in depression-linked variants functionally assayed in mouse brain

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Extensive sex differences in depression-linked variants functionally assayed in mouse brain [Hippocampus]

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Extensive sex differences in depression-linked variants functionally assayed in mouse brain [Hippocampus]

Project description:Extensive sex differences in depression-linked variants functionally assayed in mouse brain [Hippocampus]

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Extensive sex differences in depression-linked variants functionally assayed in mouse brain [Hippocampus II]

Project description:Extensive sex differences in depression-linked variants functionally assayed in mouse brain [Hippocampus II]

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Extensive sex differences in depression-linked variants functionally assayed in mouse brain

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-02-10 | GSE186348 | GEO

P10 knockout

Project description:Mice used were in a mixed background between 129/SvEv and C57BL/6. They were Rp1 knockout mice (Rp1-/-). Triplicates of RNA samples from Rp1-/- neural retinas for hybridization were collected at P10. Each RNA sample included a pool of neural retinas from 3-4 mice. Retinas were all collected at 1-2 pm of the day. Keywords: repeat sample

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Project description:Gene expression profiling was significantly different between der(1;7)(q10;p10) and -7/7q- patients by cluster analysis. There were total 1628 dysregulated genes in both der(1;7)(q10;p10) and -7/del(7q) cohorts.

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P10 wildtype

Project description:Mice used were in a mixed background between 129/SvEv and C57BL/6. They were wildtype littermates of Rp1-/- mice used in parallel experiments. Triplicates of RNA samples from Rp1+/+ neural retinas for hybridization were collected at P10. Each RNA sample included a pool of neural retinas from 3-4 mice. Retinas were all collected at 1-2 pm of the day. Keywords: repeat sample

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