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Extensive sex differences in depression-linked variants functionally assayed in mouse brain [Hippocampus II]

ABSTRACT: Extensive sex differences in depression-linked variants functionally assayed in mouse brain [Hippocampus II]

PROVIDER: PRJNA918422 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22975223.fastq.gz	Fastqsanger.gz
	SRR22975224.fastq.gz	Fastqsanger.gz
	SRR22975225.fastq.gz	Fastqsanger.gz
	SRR22975226.fastq.gz	Fastqsanger.gz
	SRR22975227.fastq.gz	Fastqsanger.gz

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Extensive sex differences in depression-linked variants functionally assayed in mouse brain [Hippocampus]

Project description:Here, we selected >1000 variants from over 30 depression-associated loci using brain epigenomic data, and functionally assayed them using in vivo functional assays in the mouse brain to examine sex-by-genotype interactions. We identify extensive sex-by-allele effects in mature hippocampus, suggesting genetic risk and thus disease mechanisms may be distinct between the sexes. Unbiased informatics approaches indicated a role for nuclear hormone receptors, which was supported by . Further, comparative analysis of allelic function in the neonatal mouse brain, during a key between developmental neonates during the masculinizing testosterone surge, and in the adult hippocampus—a region of interest in depression pathology—but not at 10 days old, a older hormonally quiescent developmental stage juveniles. Our study provides novel insights into depression genetics as influenced by age, biological sex, and cell type, and provides a framework for in vivo parallel assays at a scale not previously shown possible to functionally define interactions between sex and disease variation.

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Expression data from the hippocampus of LPS induced depression mice model treated with Luteolin

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