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Low dose interleukin-2 treatment selectively expands circulating regulatory T cells but fails to promote their trafficking into the liver and the induction of liver transplant tolerance

ABSTRACT: Low dose interleukin-2 treatment selectively expands circulating regulatory T cells but fails to promote their trafficking into the liver and the induction of liver transplant tolerance

PROVIDER: PRJNA774643 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16574874_1.fastq.gz	Fastqsanger.gz
	SRR16574874_2.fastq.gz	Fastqsanger.gz
	SRR16574875_1.fastq.gz	Fastqsanger.gz
	SRR16574875_2.fastq.gz	Fastqsanger.gz
	SRR16574876_1.fastq.gz	Fastqsanger.gz

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Low dose interleukin-2 treatment selectively expands circulating regulatory T cells but fails to promote their trafficking into the liver and the induction of liver transplant tolerance

Project description:Low dose interleukin-2 (LDIL-2) can effectively expand endogenous circulating regulatory T-cells (Tregs) in vivo, but its role in promoting allograft tolerance in humans has not been investigated. We conducted a clinical trial in stable liver transplant recipients to determine the capacity of LDIL-2 to suppress allospecific immune responses and allow the complete discontinuation of maintenance immunosuppression (clinicaltrials.gov NCT02949492). LDIL-2 treatment achieved a marked and sustained increase in circulating Tregs in all patients. However, this was not associated with the preferential expansion of donor-reactive Tregs, did not promote the accumulation of Tregs within the liver allograft, failed to induce tolerance and primed the allograft for rejection even before immunosuppression weaning was initiated.

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