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RNA-seq analysis of human monocytes exposed to lentivirus expressing shRNA against ETV3 or ETV6 during differentiation

ABSTRACT: RNA-seq analysis of human monocytes exposed to lentivirus expressing shRNA against ETV3 or ETV6 during differentiation

PROVIDER: PRJNA780934 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16959516_1.fastq.gz	Fastqsanger.gz
	SRR16959516_2.fastq.gz	Fastqsanger.gz
	SRR16959517_1.fastq.gz	Fastqsanger.gz
	SRR16959517_2.fastq.gz	Fastqsanger.gz
	SRR16959518_1.fastq.gz	Fastqsanger.gz

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RNA-seq analysis of human monocytes exposed to lentivirus expressing shRNA against ETV3 or ETV6 during differentiation

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Project description:In order to investigate the mechanism whereby TEL-PDGF-beta (ETV6-PDGFRB) interferes with human hematopoietic progenitors proliferation and differentiation, we analyzed the gene expression response downstream this oncogene. CD34+ cells infected with lentivirus coding for TEL-PDGFRb were cultured for 7 days in the absence of cytokines. Using Affymetrix microarrays, we compared gene expression in these cells and in cells treated for 4 h with low dose imatinib (Glivec), a potent PDGFR inhibitor, to switch off TEL-PDGFRb signaling.

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