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The RNA sequencing analysis of nasopharyngeal carcinoma (NPC) cell line S18 upon circIPO7 knockdown

ABSTRACT: The RNA sequencing analysis of nasopharyngeal carcinoma (NPC) cell line S18 upon circIPO7 knockdown

PROVIDER: PRJNA783044 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17022018_1.fastq.gz	Fastqsanger.gz
	SRR17022018_2.fastq.gz	Fastqsanger.gz
	SRR17022019_1.fastq.gz	Fastqsanger.gz
	SRR17022019_2.fastq.gz	Fastqsanger.gz
	SRR17022020_1.fastq.gz	Fastqsanger.gz

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The RNA sequencing analysis of nasopharyngeal carcinoma (NPC) cell line S18 upon circWDR37 knockdown

Project description:Circular RNAs have been demonstrated to play significant roles in multiple biological processes, such as immune responses and tumorigenesis, suggesting it might be potential therapeutic targets. However, the function and mechanisms of circRNAs in nasopharyngeal carcinoma (NPC) metastasis remain largely unknown. In this study, we identified circWDR37 as a metastasis related circRNA. To further explore the underlying mechanism of circWDR37 promoting NPC metastasis, we performed RNA sequencing analysis of NPC cell line S18 upon circWDR37 knockdown.

2023-03-22 | GSE207871 | GEO

The RNA sequencing analysis of nasopharyngeal carcinoma (NPC) cell line S18 upon circIPO7 knockdown

Project description:The development of therapeutic resistance and metastatic dissemination takes place in 20-30% patients with nasopharyngeal carcinoma (NPC), resulting in poor survival. Hence, a better understanding of the underlying molecular mechanisms will help improve clinical outcome. We have identified a novel circRNA, circIPO7, as a promoter of metastasis and cisplatin chemoresistance in NPC cells. High-throughput RNA sequencing analysis was performed in the human nasopharyngeal carcinoma cell line S18 after transfection with control siRNA or circIPO7 siRNA.

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The RNA sequencing analysis of nasopharyngeal carcinoma (NPC) cell line S18 upon circWDR37 knockdown

Project description:The RNA sequencing analysis of nasopharyngeal carcinoma (NPC) cell line S18 upon circWDR37 knockdown

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Microarray expression profiles in S18 and S26 human nasopharyngeal carcinoma cell lines

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Project description:The development of therapeutic resistance and metastatic dissemination takes place in 20-30% patients with nasopharyngeal carcinoma (NPC), resulting in poor survival. Hence, a better understanding of the underlying molecular mechanisms will help improve clinical outcome. We have identified a novel circRNA, circIPO7, as a promoter of metastasis and cisplatin chemoresistance in NPC cells. circIPO7 was found to bind to YBX1. Genome binding/occupancy profiling by high throughput sequencing were performed to explore the underlying molecular mechanisms.

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