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RNA sequencing of SF3B4 knockdown by siRNA in ovarian cancer cells

ABSTRACT: RNA sequencing of SF3B4 knockdown by siRNA in ovarian cancer cells

PROVIDER: PRJNA786621 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17145427_1.fastq.gz	Fastqsanger.gz
	SRR17145427_2.fastq.gz	Fastqsanger.gz
	SRR17145428_1.fastq.gz	Fastqsanger.gz
	SRR17145428_2.fastq.gz	Fastqsanger.gz
	SRR17145429_1.fastq.gz	Fastqsanger.gz

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RNA sequencing of SF3B4 knockdown by siRNA in ovarian cancer cells

Project description:In this study, SF3B4 was found to be upregulated in ovarian cancer patients and its high expression predicted poor prognosis. High expression of SF3B4 was involved in the malignant proliferation and mobility of ovarian cancer. SF3B4 could be a promising biomarker and effective therapeutic target for ovarian cancer.

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RNA sequencing (RNA-SEQ) of RECQL4 knockdown by siRNA in ovarian cancer cells

Project description:The high frequency of somatic copy number alterations, as opposed to point mutations, is considered a unique feature of high-grade serous ovarian carcinoma (HGSOC). Amplification-dependent overexpression of RECQL4, which participates in DNA replication and repair, mediates the development of various cancers, but its pathobiological and clinical roles are poorly understood. Here, using bioinformatics analysis, RECQL4 amplification was found to occur in 27% of HGSOC samples in the TCGA cohort. RECQL4 was found to be upregulated and associated with a poor prognosis based on the immunohistochemistry staining of HGSOC. Functionally, RECQL4 overexpression increased proliferation and invasion of ovarian cancer cells both in vitro and in vivo. RECQL4 silencing had the opposite effects. In addition, RECQL4 knockdown enhanced the sensitivity of ovarian cancer cells to cisplatin and PARP inhibitor (PARPi). Further mechanistic investigations revealed that MAFB was a downstream target of RECQL4. The oncogenic effect of RECQL4 was attenuated after MAFB knockdown. Moreover, RECQL4 overexpression was negatively regulated by the tumour suppressor miR-10a-5p. Collectively, these findings indicate that genomic amplification and low expression of miR-10a-5p contribute to RECQL4 overexpression in ovarian cancer. This is the first study to reveal the oncogenic functions and clinical significance of RECQL4 in ovarian cancer.

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siRNA-mediated knockdown

Project description:siRNA-mediated knockdown

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Effects of FGFRL1 knockdown on gene expression in ovarian cancer cell lines

Project description:Analysis of ovarian cancer cell lines after knockdown of FGFRL1 using SiRNA. To elucidate the signaling pathways that were significantly altered following the silencing of FGFRL1 expression, we performed global gene profiling experiments of the OVCAR8 and ES2 cells after knockdown of FGFRL1 using siRNA. We conducted pathway analysis with the differentially expressed genes using R in two OC cells.

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