Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Epigenetic remodeling during monolayer cell expansion reduces regeneration potential

ABSTRACT: Epigenetic remodeling during monolayer cell expansion reduces regeneration potential

PROVIDER: PRJNA786775 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17154979_1.fastq.gz	Fastqsanger.gz
	SRR17154979_2.fastq.gz	Fastqsanger.gz
	SRR17154980_1.fastq.gz	Fastqsanger.gz
	SRR17154980_2.fastq.gz	Fastqsanger.gz
	SRR17154981_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Epigenetic remodeling during monolayer cell expansion reduces regeneration potential

Project description:The purpose of this study was to understand the how the supression of H3K9me3 impacts the phenotype of chondrocytes during a monolayer expansion process which causes chondrocyte dedifferentiation. Therefore, we compared the mRNA expression profiles of chondrocytes isolated from H3K9M (inducible histone H3.3 lysine-to-methionine mutant) and H3WT (inducibly expressed wild-type H3.3) after 16 population doublings.

2023-05-03 | GSE190339 | GEO

Nuclear expansion drives chromatin structure remodeling in aging neurons

Project description:Nuclear expansion drives chromatin structure remodeling in aging neurons

| PRJNA1126648 | ENA

Neural induction (N2B27 monolayer cluture)

Project description:Neural induction of ES by N2B27 monolayer culture Neural induction of ES by N2B27 monolayer culture

2006-01-22 | E-GEOD-4076 | biostudies-arrayexpress

Neural induction (N2B27 monolayer cluture)

Project description:Neural induction of ES by N2B27 monolayer culture Keywords: development or differentiation design,time series design

2006-01-23 | GSE4076 | GEO

Gene expression profiles in human duodenal organoid-derived monolayer

Project description:The human small intestine is the key organ for absorption, metabolism, and excretion of orally administered drugs. To preclinically predict these reactions in drug discovery research, a cell model that can precisely recapitulate the in vivo human intestinal monolayer is desired. Here, we developed a monolayer platform using human biopsy-derived duodenal organoids for application to pharmacokinetic studies. The human duodenal organoid-derived monolayer was prepared by a simple method in 3–8 days. It consisted of polarized absorptive cells and had a barrier function. It showed much higher cytochrome P450 (CYP) 3A4 and carboxylesterase (CES) 2 activities than Caco-2 cells. It also showed efflux activity of P-glycoprotein (P-gp) and inducibility of CYP3A4. Finally, its gene expression profile was closer to the adult human duodenum, compared to the profile of Caco-2 cells. Based on these findings, this monolayer assay system using biopsy-derived human intestinal organoids is likely to be widely adopted.

2021-05-19 | GSE160695 | GEO

Monoclonal Antibody to Marinobufagenin Downregulates TGFβ Profibrotic Signaling in Left Ventricle and Kidney and Reduces Tissue Remodeling in Salt‐Sensitive Hypertension [LV_Kidney]

Project description:Elevated levels of an endogenous Na/K‐ATPase inhibitor marinobufagenin accompany salt‐sensitive hypertension and are implicated in cardiac fibrosis. Immunoneutralization of marinobufagenin reduces blood pressure in Dahl salt‐sensitive (Dahl‐S) rats. The effect of the anti‐marinobufagenin monoclonal antibody on blood pressure, left ventricular (LV) and renal remodeling, and LV gene expression were investigated in hypertensive Dahl‐S rats.

2022-07-12 | GSE208009 | GEO

AR function is altered by polyglutamine expansion and by SUMO

Project description:Expansion of a polyglutamine (polyQ) tract in the gene for the androgen receptor (AR) results in partial loss of transactivation function and causes spinobulbar muscular atrophy (SBMA). Modification of AR by small ubiquitin-like modifier (SUMO) reduces AR function in a promoter context-dependent manner. We used microarrays to confirm and demonstrate loss of AR function from polyQ expansion and to test the degree to which AR function is altered by preventing polyQ AR SUMOylation. PC12 cells expressing AR10Q, AR112Q, or nonSUMOylatable AR112Q (KRKR) in the presence or absence of synthetic androgen R1881 were assessed for alterations in AR function by comparing gene expression changes with each AR variant in response to ligand.

2014-08-23 | E-GEOD-50383 | biostudies-arrayexpress

Tipifarnib Reduces Circulating Extracellular Vesicles and Protects Against Pressure Overload-mediated Cardiac Remodeling and Dysfunction

Project description:Tipifarnib Reduces Circulating Extracellular Vesicles and Protects Against Pressure Overload-mediated Cardiac Remodeling and Dysfunction

| PRJNA1106172 | ENA

Gene expression of C28/I2 cells in monolayer and spheroid culture

Project description:Here we described the transcriptional differences of chondrocytes in monolayer and spheroid cultures.

2023-04-18 | GSE224598 | GEO

Coupled myovascular expansion directs cardiac growth and regeneration

Project description:Coupled myovascular expansion directs cardiac growth and regeneration

| PRJNA699573 | ENA