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Epigenetic remodeling during monolayer cell expansion reduces regeneration potential

ABSTRACT: Epigenetic remodeling during monolayer cell expansion reduces regeneration potential

PROVIDER: PRJNA786775 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17154979_1.fastq.gz	Fastqsanger.gz
	SRR17154979_2.fastq.gz	Fastqsanger.gz
	SRR17154980_1.fastq.gz	Fastqsanger.gz
	SRR17154980_2.fastq.gz	Fastqsanger.gz
	SRR17154981_1.fastq.gz	Fastqsanger.gz

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Epigenetic remodeling during monolayer cell expansion reduces regeneration potential

Project description:The purpose of this study was to understand the how the supression of H3K9me3 impacts the phenotype of chondrocytes during a monolayer expansion process which causes chondrocyte dedifferentiation. Therefore, we compared the mRNA expression profiles of chondrocytes isolated from H3K9M (inducible histone H3.3 lysine-to-methionine mutant) and H3WT (inducibly expressed wild-type H3.3) after 16 population doublings.

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Epigenetic remodeling for regeneration progam activation in human cells [bulkRNA]

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