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Rapid Acceleration of Diagnostics - Radical (RADx-rad): COVID-19 Detection through Scent Analysis with a Compact GC Device

ABSTRACT: Rapid Acceleration of Diagnostics - Radical (RADx-rad): COVID-19 Detection through Scent Analysis with a Compact GC Device

PROVIDER: PRJNA789983 | ENA |

REPOSITORIES: ENA

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Rapid Acceleration of Diagnostics - Radical (RADx-rad): COVID-19 Detection through Scent Analysis with a Compact GC Device

Project description:Rapid Acceleration of Diagnostics - Radical (RADx-rad): COVID-19 Detection through Scent Analysis with a Compact GC Device

| PRJNA789984 | ENA

Transcriptomics de novo analysis of Chinese Narcissus tazetta var. chinensis cv Jinzhanyintai for its floral scent

Project description:Chinese narcissus is well-known monocot plants with beautiful color, fresh and sweet floral scent. A lack of transcriptomic and genomic information hinders our understanding of the molecular mechanisms of narcissus floral scent volatiles biosynthesis. Hence, we hypothesized the functions of the significant differentially expressed genes (DEGs) identified using Illumina RNA-Seq technology, according to public protein annotation databases in this study.

2020-02-18 | GSE126727 | GEO

Rapid Acceleration of Diagnostics - Radical (RADx-rad): Portable GC Detector for COVID Diagnostics

Project description:Rapid Acceleration of Diagnostics - Radical (RADx-rad): Portable GC Detector for COVID Diagnostics

| PRJNA761805 | ENA

Rapid Acceleration of Diagnostics - Radical (RADx-rad): Portable GC Detector for COVID Diagnostics

Project description:Rapid Acceleration of Diagnostics - Radical (RADx-rad): Portable GC Detector for COVID Diagnostics

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Rapid Acceleration of Diagnostics - Radical (RADx-rad): MOF-SCENT: Metal-organic Frameworks for Screening COVID-19 by Electronic-Nose Technology to Improve Selectivity and Time Response

Project description:Rapid Acceleration of Diagnostics - Radical (RADx-rad): MOF-SCENT: Metal-organic Frameworks for Screening COVID-19 by Electronic-Nose Technology to Improve Selectivity and Time Response

| PRJNA750210 | ENA

Rapid Acceleration of Diagnostics - Radical (RADx-rad): MOF-SCENT: Metal-organic Frameworks for Screening COVID-19 by Electronic-Nose Technology to Improve Selectivity and Time Response

| PRJNA750183 | ENA

Rapid Acceleration of Diagnostics - Radical (RADx-rad): AICORE-kids

Project description:Rapid Acceleration of Diagnostics - Radical (RADx-rad): AICORE-kids

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Rapid Acceleration of Diagnostics - Radical (RADx-rad): AICORE-kids

Project description:Rapid Acceleration of Diagnostics - Radical (RADx-rad): AICORE-kids

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PepS: a microfluidic device to process whole blood at bedside for plasma proteomic analyses

Project description:Immunoassays have been used for decades in clinical laboratories to quantify proteins in serum/plasma samples. However, different limitations hinder their use in some cases. Mass spectrometry (MS)-based proteomics analysis has recently appeared as a promising option to assess panels of protein biomarkers and provide protein profiles useful for health state monitoring. Nevertheless, translation of MS-based proteomics into the clinics is still hampered by the complexity, the substantial time and human workforce necessary for sample preparation. The processing of plasma matrix is especially tricky as it contains more than 3000 proteins spanning in an extreme dynamic range (10e10) of concentrations. To address this pre-analytical challenge, we have conceived a microfluidic device (PepS) to automate and accelerate blood sample preparation for bottom-up MS-based proteomic analysis. The microfluidic cartridge is operated through a dedicated compact instrument providing fully automated fluid processing and thermal control. In less than 2 hours, PepS device enables whole blood collection at the bedside, plasma separation and calibration, depletion of albumin, protein digestion with trypsin and stabilization of tryptic peptides on solid phase extraction sorbent. The performance of PepS device was assessed using discovery proteomics and targeted proteomics on a panel of three protein biomarkers routinely assayed in clinical laboratories. This innovative microfluidic device and associated instrumentation is expected to streamline and simplify clinical proteomic studies.

2021-01-04 | PXD019403 | Pride

PRDM16 Functions as A Compact Myocardium-Enriched Transcription Factor Required to Maintain Compact Myocardial Cardiomyocyte Identity in Left Ventricle (Spatial Transcriptomics)

Project description:The loss of compact myocardial cardiomyocyte (compact CM) identity suggests that PRDM16 deficiency may dramatically alter the cellular composition in left ventricular (LV) compact myocardium. To test this hypothesis, we performed single-cell RNA-seq (scRNA-seq) to examine gene dysreulation in Prdm16cKO heart. We also performed Visium Spatial Transcriptomics (ST) to facilitate mapping CM clusters to their original locations in the heart. As a result, we were able to demonstrate gene misregulation in Prdm16cKO mouse mainly occurred in LV compact CM.

2021-12-20 | GSE179392 | GEO

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