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An intersegmental single-cell profile reveals aortic heterogeneity [AAA]

ABSTRACT: An intersegmental single-cell profile reveals aortic heterogeneity [AAA]

PROVIDER: PRJNA790625 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17272600_1.fastq.gz	Fastqsanger.gz
	SRR17272600_2.fastq.gz	Fastqsanger.gz
	SRR17272599_1.fastq.gz	Fastqsanger.gz
	SRR17272599_2.fastq.gz	Fastqsanger.gz

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An intersegmental single-cell profile reveals aortic heterogeneity [aorta]

Project description:An intersegmental single-cell profile reveals aortic heterogeneity [aorta]

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An intersegmental single-cell profile reveals aortic heterogeneity [aorta]

Project description:The continuous inter-segmental aortic profile has been rarely reported at the single-cell level. To reveal aortic heterogeneity, we identified 15 cell subtypes from five continuous aortic segments by marker genes and functional definitions. In conclusion, our study provides a more comprehensive segmental single-cell transcriptome of the aorta at the physiological level, inspiring new ideas for diagnosis and intervention targets in the pathogenesis of aortic diseases. Furthermore, a novel construction system of VSMCs was proposed to replace the traditional classification.

2022-05-02 | GSE193265 | GEO

An intersegmental single-cell profile reveals aortic heterogeneity [AAA]

Project description:According to the new scRNA-seq data after batch correction, we obtained 22, 975 cells totally isolated from aortic tissues of three groups including healthy abdominal aorta group (AA group), Ang II+ DMSO group (D_A group) and Ang II+ Inhibitor group (IN_A group)

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RNA-sequencing of abdominal aortic aneurysm (AAA) and control abdominal aorta tissues

Project description:Abdominal aortic aneurysm (AAA) is a permanent segmental dilatation of the abdominal aorta, contributing to a high mortality once rupture. We performed RNA-sequencing analysis of abdominal aorta tissues from 14 participants, including seven patients with AAA and seven control individuals.

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MicroRNA transciptional profiling in murine abdominal aortic aneurysm (AAA), porcine pancreatic elastase (PPE) model - Day 7

Project description:We sought to identify differentially regulated microRNAs in infrarenal mouse aortic tissue after AAA-induction with PPE, compared with sham-operated mice. This treatment leads to rapid development of infrarenal aortic aneurysms with significant diameter differences observed by Day 7. We found 41 miRNAs were up-regulated with aneurysm and 37 down-regulated at p<0.05, which were also altered by >1.5-fold. Utilizing the PPE infusion model, we induced AAA in Male 10-week-old C57/Bl6 mice, 7 days after AAA-induction with PPE. One array per mouse, 5 mice per group, two groups (PPE and sham).

2014-08-31 | E-GEOD-51226 | biostudies-arrayexpress

Gene expression data from aortic tissues of PPE-AAA mice receiving systemic lenvatinib treatment

Project description:Abdominal aortic aneurysm (AAA) is a disease with high morbidity and mortality, especially when ruptured. The rationale of this study was to evaluate the repurposing of lenvatinib, a multi–tyrosine kinase inhibitor, in limiting experimental AAA growth targeting vascular smooth muscle cells (VSMCs) and angiogenesis. We applied systemic lenvatinib treatment to porcine pancreatic elastase(PPE)-induced murine aortic aneurysms and profiled their gene expression through Affymetrix MTA1-0 microarray.

2023-03-07 | GSE226736 | GEO

Murine Abdominal Aortic Aneurysm, PPE Model: Transcriptional Profiling of Sham vs. AAA at Day 7

Project description:Transcriptional profiling of infrarenal aortic tissue from Male 10-week-old C57BL/6J mice after AAA-induction with porcine pancreatic elastase, compared with sham-operated mice. Includes samples obtained 7 days after aneurysm induction. Goal was to examine gene expression in developing AAA in this model, and compare with miRNA profiling performed using the same tissue. Two condition experiment, one infrarenal aorta per array. Sham vs. PPE at Day 7 post-operatively. Total 10 arrays: 5 sham D7, 5 PPE D7.

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Differential gene expression in the proximal neck of human abdominal aortic aneurysm

Project description:The aim of this study was to assess the gene expression profile of biopsies obtained from the neck of human AAAs. Genome-wide expression analysis of AAA neck specimen obtained from 14 patients with AAA (mean maximum aortic diameter=62.6±18.0 mm). Relative aortic gene expression was compared with that of 8 control aortic specimen of organ donors.

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Single-cell RNAseq analysis of CaCl2-induced mouse abdominal aortic aneurysm (AAA) samples

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