Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Fish skin mucosal microbiota

ABSTRACT: fish skin mucosal microbiota Raw sequence reads

PROVIDER: PRJNA792590 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17376326_1.fastq.gz	Fastqsanger.gz
	SRR17376326_2.fastq.gz	Fastqsanger.gz
	SRR17376327_1.fastq.gz	Fastqsanger.gz
	SRR17376327_2.fastq.gz	Fastqsanger.gz
	SRR17376328_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 80

Similar Datasets

Mucosal Immunity of Puffer Fish against bacterial Infection

Project description:This study established immunological and particularly antibacterial proteins in the skin mucus of Obscure puffer against A. hydrophila infection. These proteins could be potential biomarkers to be studied for prevention of bacterial disease in fish. Overall, the study provides primary insights into the mucosal immune factors in the skin mucus of fish and recommends each protein for functional-based molecular studies.

2024-08-16 | PXD054382 | Pride

Fish microbiota

Project description:Wild fish microbiota

| PRJNA1068742 | ENA

Homo sapiens gastrointestinal mucosal associated microbiota

Project description:Homo sapiens gastrointestinal mucosal associated microbiota Raw sequence reads

| PRJNA790678 | ENA

Freshwater fish microbiota

Project description:Freshwater fish microbiota

| PRJNA807499 | ENA

Skin Deep: Early Mucosal Responses in Blue Catfish (Ictalurus furcatus) Skin to Aeromonas hydrophila Infection

Project description:Fish skin is a critical regulatory organ, serving not only as a physical barrier to pathogen entry, but also as a sophisticated integrator of aquatic environmental, social and nutritional cues through roles in immunity, osmoregulation, and endocrine signaling. Integral to the complexity of teleost skin is the mucus layer secreted by epidermal goblet cells. Pathogen invasion can disrupt this delicate homeostasis with profound impacts on signaling throughout the organism. Here, we investigated the transcriptional effects of virulent A. hydrophila infection in blue catfish skin, Ictalurus furcatus. We utilized an 8X60K Agilent microarray to examine gene expression profiles at critical early timepoints following challenge—2 h, 12 h, and 24 h. Expression of a total of 1,155 unique genes was significantly perturbed during at least one timepoint. We observed dysregulation of a number of genes involved in including antioxidant/apoptosis, cytoskeletal rearrangement, immune response, junctional/adhesion, and proteases. In particular, A. hydrophila infection rapidly altered a number potentially critical lectins, chemokines, interleukins, and other mucosal factors in a manner predicted to enhance its ability to adhere and invade the catfish host. Two-condition experiment, control vs. infected skin. Biological replicates: 3 control replicates, 3 infected replicates.3 timepoints

2014-06-17 | E-GEOD-42491 | biostudies-arrayexpress

data and information collection on 6 fish skin samples

Project description:six fish skin tissue iTRAQ for research and data provide for manuscript

2024-04-19 | PXD047789 | Pride

Gene expression in human oral mucosal fibroblasts and patient-matched skin fibroblasts

Project description:Wound healing within the oral mucosa results in minimal scar formation compared to wounds within the skin. We have recently demonstrated distinct differences in the ageing profiles of cells (oral mucosal and patient-matched skin fibroblasts) isolated from these tissues. We hypothesize that the increased replicative potential of oral mucosal fibroblasts may confer upon them preferential wound healing capacities. Passage-matched early cultures of oral mucosal fibroblasts and skin fibroblasts demonstrated distinct gene expression profiles with a number of genes linked to wound healing/tissue repair. We analyzed the gene expression profiles of oral mucosal and patient-matched skin fibroblasts for multiple patients both prior to (0h) and (6h) following a wounding stimulus. Differences in the gene expression profiles of oral mucosal and patient-matched skin fibroblasts were anlazyed for multiple patients both prior to (0h) and (6h) following a wounding stimulus. Serum starvation and subsequent stimulation provides a model for wounding and RNA extracted at 0h and 6h following this stimulus was hybridized to Affymetrix microarrays for analysis. We sought to compare the expression profiles both between oral and normal fibroblasts, in both serum depleted and stimulated conditions and also compare differences between patients.

2011-01-01 | E-GEOD-21648 | biostudies-arrayexpress

Epigenomic alterations are associated with mucosal microbiota and inflammation in inflammatory bowel disease

Project description:Mucosal host DNA methylation was associated with the presence of inflammation suggesting epigenetic changes in response to the microbiota. Hierarchical clustering of the microbiota indicated ten subgroups, whereas some were driven by certain Enterbacteriacae and Bacteroides keystone species, and which were associated with host genotype and DNA methylation profiles, but with little influence from the habitual diet.

2020-01-29 | GSE103027 | GEO

Active thrombin is produced by intestinal epithelium to control mucosal biofilm

Project description:Healthy human and mouse colon epithelium is a major source of active thrombin, released in lumen. Using germ-free animals, we demonstrated that mucosal thrombin was directly regulated by the presence of commensal microbiota. Specific inhibition of lumenal thrombin activity caused macro-, microscopic damage and transcriptomic alterations of genes involved in host-microbiota interactions. Further, lumenal thrombin inhibition impaired the spatial segregation of microbiota biofilms, allowing bacteria to invade the mucus layer and to translocate across the epithelium. Thrombin proteolyzed the biofilm matrix of reconstituted mucosa-associated human microbiota. We demonstrated a previously unknown physiological role for epithelial thrombin that constrains biofilms at mucosal surfaces. We report that lung, bladder and skin epithelia also expressed thrombin, suggesting that this role may be applicable to other host-microbiome surfaces. Our discovery points route to new therapies targeting biofilms, important for a broad range of disorders, in the gut, and beyond.

2019-06-24 | PXD014315 | Pride

Gene expression in human oral mucosal fibroblasts and patient-matched skin fibroblasts

2011-01-01 | GSE21648 | GEO