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ICLIP of endogenous PURA in HeLa cells

ABSTRACT: iCLIP of endogenous PURA in HeLa cells

PROVIDER: PRJNA798377 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR17653888.fastq.gz	Fastqsanger.gz
	SRR17653889.fastq.gz	Fastqsanger.gz

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iCLIP of endogenous PURA in HeLa cells

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Project description:Here, we show that PURA predominantly resides in the cytoplasm, where it binds to a large set of transcripts. Many of these transcripts change abundance in response to PURA depletion, in parts reflected in altered protein expression levels. A closer inspection of the regulated proteins indicates a role of PURA in immune responses, mitochondrial function, autophagy and processing (P)-body activity.

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