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Transcriptomics analysis reveals the molecular mechanisms of the antibacterial activity of gallium nitrate against Acinetobacter baumannii isolated from bloodstream infections

ABSTRACT: Transcriptomics analysis reveals the molecular mechanisms of the antibacterial activity of gallium nitrate against Acinetobacter baumannii isolated from bloodstream infections

PROVIDER: PRJNA800015 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17717469_1.fastq.gz	Fastqsanger.gz
	SRR17717469_2.fastq.gz	Fastqsanger.gz
	SRR17717470_1.fastq.gz	Fastqsanger.gz
	SRR17717470_2.fastq.gz	Fastqsanger.gz
	SRR17717471_1.fastq.gz	Fastqsanger.gz

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Transcriptomics analysis reveals the molecular mechanisms of the antibacterial activity of gallium nitrate against Acinetobacter baumannii isolated from bloodstream infections

Project description:Purpose: The aim of this study was to explore the antibacterial effect and molecular mechanism of gallium nitrate [Ga(NO 3 ) 3 ] against Acinetobacter baumannii from bloodstream infection. Methods: A total of 40 A. baumannii with different antimicrobials susceptibility patterns were isolated from bloodstream infections. In vitro antibacterial effect of Ga(NO 3 ) 3 was analyzed by micro-dilution method and time-kill assay. The effect of ferric chloride/heme on the antibacterial effect of Ga(NO 3 ) 3 was evaluated. Transcriptome sequencing was performed to elucidate the antibacterial mechanism of gallium nitrate. Mouse infection model was conducted to explore the in vivo efficacy of gallium nitrate . Results: Ga(NO 3 ) 3 exhibited excellent antibacterial effect in RPMI 1 640 medium containing 10% human serum (MICs ranged from 0.06 μg/mL to 0.125 μg/mL), whereas its antibacterial effect was weakened by exogenous ferric chloride/heme. Ga(NO 3 ) 3 inhibited A. baumannii growth in a dose- and time- dependent manner. Ga(NO 3 ) 3 exerted antibacterial effect by up-regulating the expression of genes associated with biosynthesis and transport of siderophore and disrupting multiple iron dependent metabolism processes. Ga(NO 3 ) 3 significantly reduced bacterial load in the neutropenic mouse thigh infection model. Conclusions: This study revealed that Ga(NO 3 ) 3 had excellent antibacterial activity both in vivo and in vitro . It might be a potential drug for treating bloodstream infections of A. baumannii

2022-01-27 | GSE194255 | GEO

Insights into the Synergistic Antibacterial Activity of Silver Nitrate with Potassium Tellurite Against Pseudomonas aeruginosa

Project description:To investigate the individual and synergistic antibacterial mechanisms of silver nitrate and potassium tellurite, Pseudomonas aeruginosa cultures were exposed to a shock treatment of these metal salts (individually and in combination) at inhibitory concentrations. Differential gene expression was identified by contrasting each metal salt challenge against a PBS-treated control.

2023-06-15 | GSE232832 | GEO

CC398 bloodstream infections in DK

Project description:Origin of LA-MRSA CC398 bloodstream infections and skin and soft tissue infections, Denmark

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Project description:We examine the role of the gastrointestinal lymphatic tissue (GALT) in the formation of bloodstream infections in leukemia

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Insights into the Synergistic Antibacterial Activity of Silver Nitrate with Potassium Tellurite Against Pseudomonas aeruginosa

Project description:Insights into the Synergistic Antibacterial Activity of Silver Nitrate with Potassium Tellurite Against Pseudomonas aeruginosa

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RNAi against DRBD18 in Trypanosoma brucei bloodstream forms

Project description:RNAi against DRBD18 in Trypanosoma brucei bloodstream forms

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Outbreak of Staphylococcus haemolyticus nosocomial bloodstream infections in French neonatal intensive care units

Project description:Outbreak of S. haemolyticus nosocomial bloodstream infections in French NICU

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In-vitro evaluation of Pseudomonas fluorescens antibacterial activity against Listeria spp. isolated from New Zealand horticultural environments

Project description:Beneficial bacteria with antibacterial properties are an attractive alternative to chemical-based antibacterial or bactericidal agents. The aim of our study was to source such bacteria from horticultural produce and environments and to explore the mechanisms of their antimicrobial properties. Four strains of Pseudomonas fluorescens were isolated that possessed antibacterial activity against the pathogen Listeria monocytogenes.

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nitrate induction - nlp mutants-Nitrate induction - nlp mutants

Project description:bra-inra09-02_bioen_nitrogen - nitrate induction - nlp mutants - Short term nitrate induction kinetics in wildtype, nlp7-1, nlp7-3 and nlp6nlp7 - 10 days old seedling grown in liquid culture on 3mM nitrate wer starvec for N for 3 days and the kinetic for the resupply of nitrate was studied during a short kinetic (0,5, 10,20 minutes).

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Neonates with Gram-negative bloodstream infections (GN-BSI)

Project description:THE CORRELATION BETWEEN ANTIBIOTIC SUSCEPTIBILITY, VIRULOME, AND CLINICAL OUTCOME IN EUROPEAN INFANTS LESS THAN 90 DAYS AFFECTED BY BLOODSTREAM INFECTIONS CAUSED BY ENTEROBACTERALES

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