Project description:We conducted comparative genome hybridization experiments to catalogue the common copy number variation evident between 269 individuals from three geographically distinct human populations (Yoruban, Chinese/Japanese, European) against a single reference individual.
Project description:To understand the molecular basis of distinct pork quality in Chinese indigenous and Western breed, longissimus dorsi samples were collected from three adult Northeastern Indigenous and from three adult Large White. Total RNA was extracted and subjected to porcine Affymetrix Genechip. The study helps to elucidate the genetic mechnism of divergent pork quality and provide the theory basis for selection and genetic improvement of meat quality traits in porcine.
2016-09-02 | GSE24192 | GEO
Project description:An intercross population study identifies crucial genes associated with economically important traits in domestic geese
| PRJNA1043749 | ENA
Project description:An intercross population study identifies crucial genes associated with economically important traits in domestic geese
Project description:In order to efficiently breed plants for climate change, it is critical to identify traits in seedlings that are effective predictors of agronomically important traits at maturity that could be used to screen lines. Our work shows that the response of circadian clock to changes in photoperiod in seedling Arabidopsis is predictive of bolting time and bolting-associated traits, including the degree of synchronization in bolting. Using the first ever Recombinant Inbred Lines (RILs) between African and European Arabidopsis lineages, we find distinct Quantitative Trait Loci (QTLs) associated both with the synchronicity of circadian responses to photoperiodic changes and with bolting-related traits. Two QTLs contain K-Homology Domain RNA binding proteins (KH17 and KH29) associated with splicing variants in the MADS AFFECTING FLOWERING2 and 3 (MAF2, MAF3) genes, including generating chimeric transcripts between these two adjacent genes containing the MADS-box of MAF2 and the K-box dimerisation domain of MAF3. Many of the variants in KH17 in Arabidopsis ecotypes are found within its prion-like domain and are associated with de-coupling the mean and synchronicity of flowering time. Therefore, we have identified novel potential mechanisms that link synchronised responses on a diurnal scale and a developmental scale.
Project description:Domesticated animals all show the same patterns regarding phenotypic traits and behaviour, collectively known as the domestic phenotype. All domestic chicken come from the red junglefowl. By keeping three separate populations of junglefowl and selecting for high, low or intermediate fear responses towards humans, the goal is to in the low fear group start to unlock domestic phenotypes.
Project description:The genetic and developmental mechanisms that control the decision between scale and feather growth â two profoundly different epidermal appendages, and an important developmental shift in the evolution of birds from their dinosaurian ancestors â remain poorly understood. Domestic pigeons display dramatic variation in foot epidermal appendages within a single species, and classical studies suggest that a small number of genes control much of this variation; thus pigeons provide a tractable model to understand skin appendage specification and variation. Here we show that feathered feet in pigeons are the consequence of a partial transformation of limb-type identity mediated by cis-regulatory changes in the hindlimb-specific transcription factor Pitx1 and forelimb-specific transcription factor Tbx5. We also demonstrate that ectopic hindlimb expression of Tbx5 is associated with the development of foot feathers in domestic chickens, suggesting that similar developmental mechanisms underlie phenotypic convergence in avian lineages that diverged over 100 MYA. These results show how qualitative and quantitative changes in expression of regional patterning genes can generate localized changes in organ fate and morphology, and provide a viable molecular mechanism for the evolution of hindlimb scale and feather distribution in dromaeosaurs. Examination of H3K27ac status in embryonic limb buds from two domestic pigeon breeds, racing homer and Indian fantail
Project description:Domesticated animals all show the same patterns regarding phenotypic traits and behaviour, collectively known as the domestic phenotype. All domestic chicken come from the red junglefowl. By keeping three separate populations of junglefowl and selecting for high, low or intermediate fear responses towards humans, the goal is to in the low fear group start to unlock domestic phenotypes. For this study, tissue from the cerebral hemisphere was used.
