Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Brain–muscle tissue communication prevents muscle aging by maintaining daily physiology

ABSTRACT: Brain–muscle tissue communication prevents muscle aging by maintaining daily physiology

PROVIDER: PRJNA802021 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Brain–muscle tissue communication prevents muscle aging by maintaining daily physiology

Project description:The muscle peripheral clock selects, suppresses, and integrates signals from the central clock that serve muscle homeostasis, thus revealing its critical gatekeeper function.

2024-02-01 | GSE195724 | GEO

Gene expression and muscle contractile physiology in anoles

Project description:Gene expression and muscle contractile physiology in anoles

| PRJNA839786 | ENA

Gene expression and muscle contractile physiology in anoles

Project description:Here, we use a transcriptomic apprach to identify genes associated with variation in muscle contractile physiology differences among different muscles of the same individual.

2022-05-22 | GSE203413 | GEO

Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology

Project description:Between 6-20% of the cellular proteome is under circadian control and tunes mammalian cell function with daily environmental cycles. For cell viability, and to maintain volume within narrow limits, the daily variation in osmotic potential exerted by changes in the soluble proteome must be counterbalanced. The mechanisms and consequences of this osmotic compensation have not been investigated before. In cultured cells and in tissue we find that compensation involves electroneutral active transport of Na+, K+, and Cl- through differential activity of SLC12A family cotransporters. In cardiomyocytes ex vivo and in vivo, compensatory ion fluxes confer daily variation in electrical activity. Perturbation of soluble protein abundance has commensurate effects on ion composition and cellular function across the circadian cycle. Thus, circadian regulation of the proteome impacts ion homeostasis with substantial consequences for the physiology of electrically active cells such as cardiomyocytes.

2021-06-21 | MSV000087673 | MassIVE

Muscle Transcriptomic Circuits Linked to Periarticular Physiology in End-Stage Osteoarthritis.

Project description:Muscle Transcriptomic Circuits Linked to Periarticular Physiology in End-Stage Osteoarthritis.

| PRJNA845210 | ENA

Cox7a1 mediated CIV dimerization impacts skeletal muscle physiology and cardiac injury response

Project description:The oxidative phosphorylation (OXPHOS) system is dynamic and the respiratory complexes (RCs) coexist with super-assembled quaternary structures called supercomplexes (SCs). How assembly occurs and the physiological role of supercomplex assembly is still under intensive investigation. The Cox7a family member Cox7a2l, also known as Scaf1, promotes CIII-CIV super assembly and energetic efficiency in zebrafish, mice, and humans. Here we studied the role of a second member of the Cox7a family, Cox7a1 in SC assembly and striated muscle physiology. We found that this protein drives CIV homodimer formation, which increases CIV activity. The substantial reduction in CIV2 formation led to a profound metabolic rearrangement with a consequent non-pathological loss of skeletal muscle performance. Ablation of Cox7a1 also rewired heart metabolism. Already in homeostatic conditions, cox7a1-/- hearts revealed a pro-regenerative metabolic profile. While overall cardiac function was not affected, the absence of Cox7a1 altered the cardiac regenerative response. The effects of cox7a1 and cox7a2l loss of function on skeletal muscle and myocardium physiology and injury response were not identical, revealing that there is a high specificity of Cox7a isoform in controlling OXPHOS assembly and striated muscle metabolism. While in both cases overall OXPHOS activity is modified, the loss of CIII-CIV heterodimer formation or CIV homodimer formation have very distinct metabolic and physiological consequences, highlighting the complexity of OXPHOS function and the importance of cox7a1 in striated muscle maturation.

2024-03-20 | GSE254466 | GEO

Daily cycling of genome-wide histone methylation

Project description:Daily (circadian) clocks are essential for regulating and coordinating physiology in mammals. Modulation of local chromatin structure has been shown for only a small number of genes, principally thought to be directly modulated by Clock-mediated histone acetylation. Here we show that genome-wide changes of active and suppressive histone marks control global chromatin architecture over the day and night.

2013-01-01 | GSE37393 | GEO

Cox7a1 mediated CIV dimerization impacts skeletal muscle physiology and cardiac injury response

Project description:Cox7a1 mediated CIV dimerization impacts skeletal muscle physiology and cardiac injury response

| PRJNA1070616 | ENA

Protein Recommendation to Increase Muscle

Project description:This is a feasibility study to test the potential efficacy of diets of different amounts of protein and calories for patients with cancer. We hypothesize that nutritional deficits play a significant role in muscle loss and that nutritional therapy is an important first step in reversing or preventing muscle loss and maintaining/improving physical function.

| 2216429 | ecrin-mdr-crc

Daily cycling of genome-wide histone methylation

2013-01-01 | E-GEOD-37393 | biostudies-arrayexpress