Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data from cardiac myofibroblasts treated with siControl or siVgll3

ABSTRACT: Expression data from cardiac myofibroblasts treated with siControl or siVgll3

PROVIDER: PRJNA803886 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Expression data from cardiac myofibroblasts treated with siControl or siVgll3

Project description:VGLL3 promotes the expression of collagens in cardiac myofibroblasts Fibrosis is occurred various organs and there has been reported that fibrosis contributes about 45% of all mortalities in the developed countries. In fibrosis, extracellular matrix such as collagens is mainly produced by myofibroblasts. In this time, we knocked down VGLL3 in cardiac myofibroblasts by using siRNA.

2022-12-19 | GSE196194 | GEO

Expression data from cardiac myofibroblasts culutured on plastic plates or in suspension

Project description:Identification of the genes whose expresion levels are changed by the various culture conditions in cardiac myofibroblasts

2022-12-19 | GSE158236 | GEO

Microcurrent-Mediated Modulation of Myofibroblasts for Cardiac Repair and Regeneration

Project description:Myofibroblasts are one of the key cell types in cardiac injuries, leading to scar tissue formation and reduced heart function. To investigate the impact of microcurrent treatment on these cells, primary rat cardiac fibroblasts were initially differentiated into myofibroblasts. Subsequently, the differentiated myofibroblasts were subjected to microcurrent treatment at 1 and 2 µA/cm2 direct current (DC) with and without polarity reversal. Microcurrent treatments resulted in distinct transcriptional signatures and improved cell behavior. The observations show signs of microcurrent-mediated reversal of myofibroblast phenotype, possibly reducing cardiac fibrosis, and providing insights for cardiac tissue repair.

2024-03-14 | GSE238154 | GEO

Expression data from cardiac myofibroblasts culutured on plastic plates or in suspension

Project description:Expression data from cardiac myofibroblasts culutured on plastic plates or in suspension

| PRJNA664400 | ENA

Expression data from a human lung metastatic cell line treated with siPGC1alpha or siControl

Project description:To understand global expression changes in a knockdown of PGC1alpha (siPGC1alpha) vs control (siControl) in a lung metastatic cell line (4175) Metabolic adaptations play a key role in fuelling tumour growth. However, less is known regarding the metabolic changes that promote cancer progression to metastatic disease. Herein, we reveal that PGC-1a expression and activity are differentially regulated depending on breast cancer metastatic sites. Breast cancer cells that preferentially metastasize to lung display striking upregulation of PGC-1a expression. PGC-1a promotes breast cancer cell migration and invasion in vitro and augments lung metastasis in vivo. MDA-MB-231 lung variant (4175) cells were treated with a short interfering RNA (siRNA) for human PGC-1a (PPARG1A) or control siRNA for 48hrs 24 hours post-plating cells.

2017-09-06 | GSE99554 | GEO

The effect of soluble CD74 (sCD74) and recombinant macrophage migration inhibitory factor (MIF) treatment on the gene expression profile in cardiac myofibroblasts

Project description:Co-treatment with soluble CD74 and MIF induced necroptosis in cardiac myofibroblasts. The underlying mechanism of sCD74/MIF-induced necroptosis are still unkown. We used a microarray to identify pathways regulated by co-treatment with sCD74 and MIF .

2018-11-06 | GSE108999 | GEO

Cancer-derived myofibroblasts vs. non-cancer derived myofibroblasts

Project description:All samples are conditioned media from primary cultured human gastric myofibroblasts, derived from either carcinoma tissue, or adjacent non cancerous tissue. In each experiment the cancer-derived myofibroblasts are compared against the non-cancer derived myofibroblasts from the same patient. All of the experiments were samples from Patient 1, except for 648, which is from Patient 2. SILAC labelling in each case is; 567 - Methionine COFRADIC; Cancer-derived = Heavy, Non-cancer = Light 575 - N-terminal COFRADIC; Cancer-derived = Heavy, Non-cancer = Light 646 - Cancer-derived = Light, Non-cancer = Heavy 647 - Non-cancer = Heavy, Non-cancer = Light (same cell line labelled twice to create a control experiment) 648 - Cancer-derived = Heavy, Non-cancer = Light

2013-06-20 | PRD000744 | Pride

Gene expression data from human ovarian cancer cells treated with siRNAs targeting CPNE8 and BHLHE41

Project description:To examine the role of CPNE8 and BHLHE41 in ovarian cancer cells, RMG1 cells were treated with siRNA targeting CPNE8 (siCPNE8 #A and #B) or control siRNA (siControl), and OVCAR3 cells were treated with siRNA targeting BHLHE41 (siBHLHE41 #A and #B) or control siRNA (siControl). Microarray analysis showed that CPNE8 and BHLHE41 are involved in cellular signaling pathways in ovarian cancer.

2019-08-23 | GSE125542 | GEO

Expression data from ME180 cells transfected with siControl and siSGK1

Project description:Expression data from ME180 cells transfected with siControl and siSGK1

| PRJNA540275 | ENA

Secretomes of Cancer-Associated Myofibroblasts and Normal Tissue Myofibroblasts in hypoxia and normoxia C4PR_LIV

Project description:Cancer-associated fibroblasts are a major component of the cancer stroma. Here we focus on gastric cancer associated myofibroblasts (CAMs). CAMs secrete factors that increase the migration, invasion and proliferation of cancer cells when compared to adjacent tissue myofibroblasts (ATMs), or normal tissue myofibroblasts (NTMs). In this study we identified and quantified the proteins secreted by normoxic (21% O2) and hypoxic (1% O2) myofibroblast cells.

2019-03-04 | PXD008104 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data