Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide gene expression profile of mouse proliferating / differentiating cerebellar granular progenitor cells (CGNPs)

ABSTRACT: Genome-wide gene expression profile of mouse proliferating / differentiating cerebellar granular progenitor cells (CGNPs)

PROVIDER: PRJNA805303 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17979108_1.fastq.gz	Fastqsanger.gz
	SRR17979108_2.fastq.gz	Fastqsanger.gz
	SRR17979109_1.fastq.gz	Fastqsanger.gz
	SRR17979109_2.fastq.gz	Fastqsanger.gz
	SRR17979110_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 28

Similar Datasets

Genome-wide gene expression profile of mouse proliferating / differentiating cerebellar granular progenitor cells (CGNPs)

Project description:To study the gene expression changes during neuronal differentiation of mouse cerebellar granular progenitor cells (CGNPs), we generated neurospheres (proliferating CGNPs) and differentiated the cells (differentiating CGNPs). Then we performed RNA-Seq analysis.

2022-05-04 | GSE196548 | GEO

Expression analysis of cerebellar granular cell layer isolated from PTEN conditional null mutants and controls

Project description:A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination was identified in mice that conditionally lack PTEN in cerebellar granular cells (PTEN cKO) Expression analysis was performed with RNA obtained selectively from cerebellar granular cell layer of PTEN conditional null mutants and controls

2016-09-30 | GSE80966 | GEO

Transcription profiling of rat cerebellar granular cells cultured in the presence of Shh for 24h and then pulsed with Bmp2 or vehicle for up to 24h

Project description:Proliferating cerebellar granular cells were cultured in presence of Shh for 24h (3ug/ml) and then pulsed for additional 24h with Bmp2 or vehicle. Cells then were lysed and mRNA extracted. Microarray data from cells treated with Bmp2 was referred to the control not treated with Bmp2.

2007-06-07 | E-MEXP-1129 | biostudies-arrayexpress

Expression data of proliferating and differentiating ENS progenitor cells

Project description:Postnatal neural progenitors of the enteric nervous system are a potential source for future cell replacement therapies of developmental dysplasia like Hirschrpung’s disease. However, little is known about the molecular mechanisms driving the homeostasis and differentiation of this cell pool. In this work, we conducted Affymetrix gene chip experiments to identify differences in gene regulation between proliferation and early differentiation of enteric neural progenitors. We detected a total of 1333 regulated genes that were linked to different groups of cellular mechanisms involved in cell cycle, apoptosis, neural proliferation, and differentiation. As expected, we found a strong inhibition of cell cycle progression as well as an enhanced expression of neuronal and glial markers. We further found a marked inactivation of the canonical Wnt pathway during the beginning of cellular differentiation. Taken together, this data illustrated the various mechanisms taking place during the proliferation and early differentiation of enteric neural progenitor cells. We analyzed 2 groups with 3 samples each: 1 group consistent of cells proliferating für 11 days and 1 group of enterospheres proliferating for 9 days and differentiating for 2 days before RNA extraction

2015-05-13 | E-GEOD-68797 | biostudies-arrayexpress

Gene Expression data from the differentiating and proliferating neural stem/progenitor cells

Project description:Gene Expression data from the differentiating and proliferating neural stem/progenitor cells

| PRJNA549178 | ENA

miRNA Expression data from the differentiating and proliferating neural stem/progenitor cells

Project description:miRNA Expression data from the differentiating and proliferating neural stem/progenitor cells

| PRJNA549180 | ENA

H3K79me2 ChIP-seq in cerebellar granular neurons (CGN) and progenitors (CGNP) upon DOT1L inhibition with SGC0946 in vitro

Project description:DOT1L as methyltransferase of H3K79 is implicated in brian development. Here, we further defined DOT1L function within the granular neurons during cerebellar development using ChIP-seq of H3K79 dimethylation of isolated cerebellar granular neurons and progenitors. Thereby we compared samples treated with a DOT1L inhibitor versus DMSO treated cells. The data sets reveals new important targets of DOT1L, which ensure a correct development of the cerebellum.

2018-10-15 | GSE101947 | GEO

Gene-profile comparison of wt and Ifnb–/– cerebellar granular neurons

Project description:Interferon-b (IFN-b) belongs to the type I interferon family of cytokines and via binding to its receptor, interferon-a/b-receptor (IFNAR), it exerts immunoregulatory effects such as anti-viral and anti-inflammatory properties, and clinical benefits for patients with the CNS disease multiple sclerosis. To compare differentially regulated genes in neurons of interferon-beta knock out mice (Ifnb–/–), we conducted a microarray analysis on cerebellar granular neurons (CGNs) from wt (Ifnb+/+) and Ifnb-/- mice with or without treatment with recombinant IFN-b.

2015-10-08 | GSE63815 | GEO

miRNA Expression data from the differentiating and proliferating neural stem/progenitor cells

Project description:The adverse effect of CSDS on the DG neurogenesis is expected to affect the properties of the resident NSCs/NPCs.We used neurosphere culture system, a well-established ex vivo model to study neurogenesis. We collected proliferating neurospheres and differentiating NSCs/NPCs after 7 days of plating and isolated RNA for microRNA array to identify the altered miRNAs

2019-07-17 | GSE132822 | GEO

Gene Expression data from the differentiating and proliferating neural stem/progenitor cells

Project description:The adverse effect of CSDS on the DG neurogenesis is expected to affect the properties of the resident NSCs/NPCs.We used neurosphere culture system, a well-established ex vivo model to study neurogenesis. We collected proliferating neurospheres and differentiating NSCs/NPCs from two stages, i.e. early (after 2 days) and late (after 7 days) and isolated RNA for gene arrays.

2019-07-17 | GSE132820 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data