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Transcriptomic profiles of liver tissue from hindlimb unloaded mice treated with 4-phenylbutyrate

ABSTRACT: Transcriptomic profiles of liver tissue from hindlimb unloaded mice treated with 4-phenylbutyrate

PROVIDER: PRJNA805509 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17982658_1.fastq.gz	Fastqsanger.gz
	SRR17982658_2.fastq.gz	Fastqsanger.gz
	SRR17982659_1.fastq.gz	Fastqsanger.gz
	SRR17982659_2.fastq.gz	Fastqsanger.gz
	SRR17982660_1.fastq.gz	Fastqsanger.gz

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Transcriptomic profiles of liver tissue from hindlimb unloaded mice treated with 4-phenylbutyrate

Project description:Bulk transcriptomic profiles of liver tissues from male, 18 weeks old c57Bl/6j mice, including ground-based controls, hindlimb-unloaded mice treated with vehicle, and hindlimb unloaded mice treated wit 4-phenylbutyrate (4-PBA)

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Transcriptomic profiles of testis from hindlimb unloaded mice treated with 4-phenylbutyrate

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Transcriptomic profiles of gastrocnemius muscles from hindlimb unloaded mice treated with 4-phenylbutyrate

Project description:Transcriptomic profiles of gastrocnemius muscles from 18 weeks old, male, hind muscles unloaded mice treated with vehicle or4-phenylbutyrate (4-PBA)

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Project description:Transcriptomic profiles of testis from hindlimb unloaded mice treated with 4-phenylbutyrate

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Transcriptomic profiles of gastrocnemius muscles from hindlimb unloaded mice treated with 4-phenylbutyrate

Project description:Transcriptomic profiles of gastrocnemius muscles from hindlimb unloaded mice treated with 4-phenylbutyrate

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Transcriptomic profiling of cortical bone from hindlimb unloaded mice

Project description:The goal of this study was to perform RNA-sequencing of cortical bone isolated from 11-week-old female hindlimb unloaded and control mice. Mice were subjected to hindlimb unloading for 7 days, followed by RNA isolation of cortical bone. Cortical transcriptomic profiles were assessed with RNAseq.

2021-03-23 | GSE169292 | GEO

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mRNA Expression data from sodium butyrate or sodium phenylbutyrate treated A549 cells

Project description:As a histone deacetylase inhibitor, sodium butyrate and its derivative sodium phenylbutyrate involve in cellular events such as proliferation, differentiation, apoptosis and cell cycle control via reprogramming gene expression. However, the gene associated with the cell cycle control and molecular signaling triggering cell apopotosis and death are not well elucidated. Here, we treated A549 cells,a cell line belong to the non-small cells lung cancer,with high concentration of sodium butyrate or sodium phenylbutyrate and then used microarray identified differentially-expressed mRNA during this process.

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Hindlimb unloading alters wound healing in ligaments

Project description:A recent physiological study established that hindlimb unloading of rats at 3 and 7 weeks inhibits healing of injured ligaments, resulting in a badly aligned, discontinuous collagen matrix. Using tissue from these rats, we focused on the 3-week time point employing microarray analysis to identify what cellular processes or lack of processes could account for these observed deficiencies. We used the Afyymetrix RG_U34A GeneChip and performed image analysis with Microarray Suite 5.0. For normalization we used the MAS global normalization protocol with a default target mean signal of 500. Gene expression in medial collateral ligament tissue under 4 different treatment conditions was measured: loaded control, loaded wound healing, unloaded control, and unloaded wound healing. From our results, it appears that unloaded tissue lags behind loaded tissue in its progression through the healing process and at 3 weeks is still engaged in the proliferative phase, whereas loaded tissue is actively remodeling its collagen matrix. Summary tables below: Affymetrix MAS comparative analysis data for the 1778 genes qualified for further analysis as a result of detection call values. Keywords: other

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2023-12-09 | GSE240909 | GEO

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