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Skeletal muscle specific AMPKalpha1/2 deletion during hindlimb unloading

ABSTRACT: The primary goal of this study was to determine the role of AMPKalpha during disuse atrophy. Skeletal muscle-specific tamoxifen-inducible AMPKlpha1/alpha2 double knockout (KO) mice were generated and KO was induced for 4 weeks. After 2 weeks of KO, mice were hindlimb unloaded (HU) for 2 weeks to induce atrophy or maintained ambulatory (AMB). We observed that AMPKalpha double KO impaired skeletal muscle transcriptional profiles that may have carried over with HU.

ORGANISM(S): Mus musculus

PROVIDER: GSE240909 | GEO | 2023/12/09

REPOSITORIES: GEO

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Employing Hindlimb Unloading Model for The Identification of Serum Biomarkers Associated with Cardiovascular and Skeletal Muscle Deconditioning.

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Muscle unloading and reloading

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