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Effect of formate on LN229 cells

ABSTRACT: Effect of formate on LN229 cells

PROVIDER: PRJNA806943 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18017106.fastq.gz	Fastqsanger.gz
	SRR18017107.fastq.gz	Fastqsanger.gz
	SRR18017108.fastq.gz	Fastqsanger.gz
	SRR18017109.fastq.gz	Fastqsanger.gz
	SRR18017110.fastq.gz	Fastqsanger.gz

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Effect of formate on LN229 cells

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Transcriptomic alterations upon HSP90 inhibition in human LN229 and T98 glioblastoma cells in vitro

Project description:Purpose: Characterization of transcriptomic alterations upon HPS90 inhibition in human LN229 and T98G glioblastoma cells in vitro. Methods: LN229 and T98G glioblastoma cells were treated with 10 nM of the HSP90 inhibitor NW457 or the vehicle control for 24 h, and total RNA was subjected to 3' RNA sequencing. Results: Distinct transcriptomic alterations were observed, dominated by a transcriptional upregulation of the heat shock response. Conclusion: HSP90 inhibition resulted in distinct transcriptomic alterations and a clear upregulation of the heat shock response.

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Targeting S6K1 and S6K2 by siRNA and sgRNA in LN229 GBM cells

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The effects on the deficient of GDH1 on gene expression in LN229 cells.

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Gene expression from total and polysomal RNA fractions after ATO treatment in LN229 cells.

Project description:Arsenic trioxide (ATO) treatment leads to activation of mRNA translation through the MAPK-interacting kinase (MNK) signaling pathway. Polysomal fractionation and microarray analysis allows for identification of transcripts undergoing active translation. We identified the genes differentially enriched in untreated and ATO treated fractions. In this dataset, we include expression data in untreated and ATO treated LN229 cells using either the total or polysomal RNA.

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