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Pharmacodynamics of malignant mesothelioma MSTO-211H dn-TEAD2 xenograft recurrence.

ABSTRACT: Pharmacodynamics of malignant mesothelioma MSTO-211H dn-TEAD2 xenograft recurrence.

PROVIDER: PRJNA806953 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18017800_1.fastq.gz	Fastqsanger.gz
	SRR18017800_2.fastq.gz	Fastqsanger.gz
	SRR18017801_1.fastq.gz	Fastqsanger.gz
	SRR18017801_2.fastq.gz	Fastqsanger.gz
	SRR18017802_1.fastq.gz	Fastqsanger.gz

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Pharmacodynamics of malignant mesothelioma MSTO-211H dn-TEAD2 xenograft recurrence.

Project description:We investigate the dependence of human malignant pleural mesothelioma on a functional YAP1-TEAD transcription factor complex to maintain fully established tumors in vivo. We show that, in a dysfunctional Hippo genetic background, expression of a doxycycline-dependent dominant negative TEAD2 temporarily modulates YAP1/TEAD-dependent gene expression and inhibits growth of established tumor xenografts. Recovery of tumor growth is associated with TEAD-dependent transcription comparable to untreated tumors, therefore, re-activation of TEAD transcription complexes.

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