Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The role of KDM6B in cognitive functions

ABSTRACT: The role of KDM6B in cognitive functions

PROVIDER: PRJNA809003 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18090462.fastq.gz	Fastqsanger.gz
	SRR18090463.fastq.gz	Fastqsanger.gz
	SRR18090464.fastq.gz	Fastqsanger.gz
	SRR18090465.fastq.gz	Fastqsanger.gz
	SRR18090466.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

The role of KDM6B in cognitive functions

Project description:Analysis of mRNA expression in WT and KDM6B KO neurons.

2022-08-23 | GSE197117 | GEO

The role of KDM6B in DNA damage repair

Project description:The role of KDM6B in DNA damage repair

| PRJNA790096 | ENA

Measures to improving cognitive and non cognitive functions while receiving chemotherapy for cancer of large intestine

Project description:Intervention1: Exercise and Vit D supplement: STUDY PARTICIPANTS WILL BE TAUGHT EXERCISE TO BE CARRIED OUT MINIMUM 2.5 HOURS/ WEEK FOR 12 MONTHS FROM THE TIME OF RECRUITMENT AND WILL BE GIVEN VIT D SUPPLEMENTS OF 60,000 I.U. PER WEEK TO BE CONSUMED ORALLY FOR THE 1ST 4 WEEKS FOLLOWED BY 60,000 I.U. EVERY ALTERNATE WEEK FOR 8 WEEKS THE EFFECT WILL BE MEASURED USING STANDARDISED INSTRUMENTS FOR COGNITIVE AND NON COGNITIVE FUNCTIONS Control Intervention1: Standard treatment: It will be prescribed by the treating medical oncologist Primary outcome(s): I. Primary objectives a) To assess the cognitive and non cognitive function of participants in experimental group before and after planned intervention c) To compare the cognitive function of participants in experimental and control group before and after planned intervention II. Secondary Objectives a) To assess the non- cognitive function and serum TNF alpha levels of participants in control and study group before and after planned intervention Timepoint: 0,3,6,9,and 12 months

| 2591022 | ecrin-mdr-crc

The role of KDM6B in DNA damage repair

Project description:KDM6B inhibits DNA repair gene MGMT.

2022-06-02 | GSE191196 | GEO

KDM4B- and KDM6B-regulated genes in human mesenchymal stem cell osteogenic differentiation

Project description:To investigate how histone demethylases KDM4B and KDM6B may be involved in osteogenic commitment of mesenchymal stem cells (MSCs), we performed gene expression profiling and comparison on control, KDM4B- and KDM6B-knockdown MSCs at different stages of osteogenic differentiation. Human MSCs infected with scramble shRNAs, shRNAs against KDM4B or KDM6B are treated with BMP4/7 for 0, 4 and 24hrs. Total RNA were extracted from these 9 samples.

2012-07-31 | E-GEOD-36970 | biostudies-arrayexpress

Kdm6b is Required for Self-Renewal of Normal and Leukemic Stem Cells Under Proliferative Stress

Project description:Recent studies have indicated that the histone 3 lysine 27 (H3K27me2/3) demethylase KDM6B (JMJD3) is frequently upregulated in a myriad of blood disorders including myelodysplastic syndrome (MDS), T-cell acute lymphoblastic leukemia (T-ALL), and multiple myeloma (MM) suggesting it may have important functions in the pathogenesis of hematopoietic cancers. Here, we sought to determine the role of Kdm6b in hematopoietic stem cell (HSC) fate decisions under normal and malignant conditions to evaluate its potential as a therapeutic target. We show that loss of Kdm6b leads to a significant reduction in phenotypic and functional HSCs in adult mice, and that Kdm6b is necessary for HSC self-renewal in response to inflammatory, genotoxic and oncogenic stress. Additionally, we show that loss of Kdm6b in HSCs leads to a stress-response gene expression signature in native HSCs that is independent of its demethylase activity. Loss of Kdm6b lead to increased expression of a subset of genes implicated in HSC quiescence (e.g. Fos, Jun, Ier2, Dusp1, Zfp36). Upon inflammatory or replicative stress, HSCs deficient for Kdm6b are not able to efficiently resolve this gene expression program, leading to increased quiescence and a self-renewal block, forcing them to differentiate. These findings show that Kdm6b is necessary for self-renewal of normal and leukemic stem cells, and suggest inhibiting Kdm6b in blood cancers in the presence of proliferative agents may force differentiation and eventual depletion of leukemic stem cells.

2019-07-17 | GSE110378 | GEO

Role of the histone demethylase Kdm6b/Jmjd3 in somatic cell reprogramming

Project description:Role of the histone demethylase Kdm6b/Jmjd3 in somatic cell reprogramming

| PRJNA302168 | ENA

The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival

Project description:We profiled basal and bicuculline+4-AP inducible mRNA expression in cultured mouse hippocampal neurons with or without viral shRNA mediated knockdown of Kdm6b We harvested mRNA from neurons under four conditions (pLKO vector/treatment control, pLKO vector/3hr bicuculline+4AP, Kdm6b knockdown/treatment control,Kdm6b knockdown/3hr bicuculline+4AP). Libraries were generated and used for RNA sequencing.

2014-06-12 | E-GEOD-58398 | biostudies-arrayexpress

Epigenetic reprogramming through KDM6B drives immunofibroblast early commitment and immune properties [CUT&RUN-seq]

Project description:TLS are composed of immune cells, including lymphocytes and myeloid cells, lymphatic and blood endothelial cells, and PDPN+ stromal cells with lymphoid stromal cells (LSC) features called immunofibroblasts. These LSC play a central role in the physiology of secondary lymphoid organs. Recent studies have focused on the heterogeneity of immunofibroblast and their cell of origin, but molecular and epigenetic mechanisms involved in their commitment are still unknown. In this study, we took advantage of the combination of an in vitro model of human ASC commitment to LSC/immunofibroblasts, and an in vivo model of murine TLS induction. We highlighted in both cases an early induction of KDM6B in stromal cells associated with an early epigenetic reprogramming. The KDM6B signature was enriched in sorted pathogenic stroma from patients with autoimmune diseases. Furthermore, using a KDM6 inhibitor, we demonstrated that KDM6B was required for the acquisition of immunofibroblast phenotype and functions, including upregulation of CCL2 production and monocyte recruitment. Overall, our results shed light on epigenetic mechanisms involved in the early commitment, but also immune properties of immunofibroblasts.

2023-10-23 | GSE221460 | GEO

Role of the histone demethylase Kdm6b/Jmjd3 in somatic cell reprogramming [ATAC-Seq]

Project description:Somatic cells can be reprogrammed to pluripotent stem cells through the addition of just four transcription factors, OCT4, SOX2, KLF4 and c-MYC (OSKM). Although OSKM initiates reprogramming it is clear that extensive epigenetic remodeling is required to complete reprogramming. Critically, OSKM do not directly activate gene expression but instead recruit co-activators and co-repressors that remodel the local chromatin and in some way make the cells permissive for reprogramming. Consequently understanding how epigenetic co-repressors and co-activators are involved in reprogramming is a critical step in understanding the reprogramming process in detail. In this study we explored the role of the lysine-specific demethylase Kdm6b/Jmjd3 and its role in the reprogramming of somatic cells to pluripotent cells.

2020-07-22 | GSE149500 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data