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Characterization of molecular changes associated with aging in the mouse cochlear lateral wall

ABSTRACT: Characterization of molecular changes associated with aging in the mouse cochlear lateral wall

PROVIDER: PRJNA811314 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18175925_1.fastq.gz	Fastqsanger.gz
	SRR18175925_2.fastq.gz	Fastqsanger.gz
	SRR18175926_1.fastq.gz	Fastqsanger.gz
	SRR18175926_2.fastq.gz	Fastqsanger.gz
	SRR18175927_1.fastq.gz	Fastqsanger.gz

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Characterization of molecular changes associated with aging in the mouse cochlear lateral wall

Project description:Overall goal of the study is to identify key molecular regulators that change in the cochlear lateral wall as a function of aging

2023-02-18 | GSE197634 | GEO

MicroRNAs Involved in Aging of the Lateral Wall of the Cochlear Duct

Project description:Age-related hearing loss is a progressive sensorineural hearing loss that occurs as people get older. Degeneration of the organ of Corti and atrophy of the lateral wall of the cochlear duct (or scala media) in the inner ear are the two primary causes. MicroRNAs (miRNAs), a class of short non-coding RNAs that regulate the expression of mRNA/protein targets, are important regulators of cellular senescence and aging. We examined the change of miRNA gene expression profiles in the lateral wall of the cochlear duct in two mouse strains during aging The totoal RNA was extracted from the lateral wall of cochlear duct from CBA/J and C57BL/6J mice at different ages. The expression profile of miRNAs was examined by miR microarray GeneChip.

2014-10-01 | E-GEOD-57782 | biostudies-arrayexpress

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2014-10-01 | GSE57782 | GEO

MicroRNAs as Regulators of Aging Processes in the Cochlear Lateral Wall of the Mouse Inner Ear (microRNA data set)

Project description:Age-related hearing loss (presbycusis) affects more than one-third of Americans over the age of 60, with its prevalence and severity increasing with age. Pathological alterations to the cochlear lateral wall (CLW) disrupting the maintenance of the endocochlear potential (EP) are a major cause of (metabolic) presbycusis. Although molecular mediators of CLW degeneration are largely unknown, several cellular events, including oxidative stress, apoptosis, and inhibition of proliferation, are known to contribute to this dysfunction. Here we have analyzed mRNA and microRNA expression in CLW of young and old mice to profile transcriptional changes that occur as a function of aging. Our results reinforce prior findings about molecular processes and pathways affected by aging and implicate microRNAs that may be involved in influencing these changes.

2021-04-14 | GSE98071 | GEO

MicroRNAs as Regulators of Aging Processes in the Cochlear Lateral Wall of the Mouse Inner Ear (mRNA data set)

2021-04-14 | GSE98070 | GEO

Gene expression data from rat cochlear lateral wall after 3NP damage

Project description:A rat model of acute mitochondrial dysfunction in the cochlea is created by applying an irreversible mitochondrial complex II enzyme inhibitor, 3-NP, directly to the round window membrane. Treatment with 300 mM 3-NP results in temporary hearing loss (temporary threshold shift (TTS) model), whereas treatment with 500 mM 3-NP results in profound and permanent hearing loss (permanent threshold shift (PTS) model. Either treatment results with a primary histological change in the lateral wall spiral ligament. Because local ATP deprivation in the inner ear results from inhibition of inner ear mitochondrial function, this model replicates the etiology of inner ear energy failure caused by ATP deprivation due to inner ear ischemia. We used microarrays to detail the global programme of gene expression in the damaged cochlear lateral wall by 3NP and identified distinct classes of up-regulated/ down-regulated genes during the process. One and three day after administrated either 300 mM of 3-NP (TTS-1d and TTS-3d, respectably) or saline (Ctrl-1d and Ctrl-3d, respectably), rat cochear lateral wall in the apical side of the basal turn was harvested for RNA extraction and hybridization on Affymetrix microarrays.

2013-11-20 | E-GEOD-52500 | biostudies-arrayexpress

Gene expression data from rat cochlear lateral wall after 3NP damage

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MicroRNAs as Regulators of Aging Processes in the Cochlear Lateral Wall of the Mouse Inner Ear

Project description:MicroRNAs as Regulators of Aging Processes in the Cochlear Lateral Wall of the Mouse Inner Ear

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Transcriptional profiling of cochlear spiral ganglion neurons and lateral wall cells

Project description:Transcriptional profiling of cochlear spiral ganglion neurons and lateral wall cells

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Transcriptional profiling of cochlear spiral ganglion neurons and lateral wall cells

Project description:In order to characterize the response to noise of various cell types in the inner ear, the cochleae from wild-type mice, naive or subjected to a 2h, 105 dB SPL noise insult, were dissected out. To further examine spiral ganglion neurons in more detail, non-neuronal populations were removed in one set of samples. In another set of samples, the lateral wall tissue was isolated to better understand how cells from the stria respond to noise insults. The resulting tissue was then dissociated to obtain a single cell suspension, and profiled by single cell RNA-seq.

2021-09-08 | GSE168041 | GEO

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