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The NFkB protein RELA/p65 binds predominantly transcript introns and exons

ABSTRACT: The NFkB protein RELA/p65 binds predominantly transcript introns and exons

PROVIDER: PRJNA811611 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18185544_1.fastq.gz	Fastqsanger.gz
	SRR18185544_2.fastq.gz	Fastqsanger.gz
	SRR18185545_1.fastq.gz	Fastqsanger.gz
	SRR18185545_2.fastq.gz	Fastqsanger.gz
	SRR18185546_1.fastq.gz	Fastqsanger.gz

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The NFkB protein RELA/p65 binds predominantly transcript introns and exons

Project description:We investigated the ability of the NFkB protein p65 to bind RNA and what its target transcrips were. In this CLIP-seq experiment we demonstrated that p65 is capable of binding RNA and it has a preference to introns and exons, suggesting it binds unspliced RNA.

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Effect of S534A substitution in the p65 subunit of Nfkb on response to 1mg LPS

Project description:WT mice and Nfkb/p65 S534A were exposed to 1mg/kg LPS and their gene expression measured. Affymetrix Mouse 1.0ST chips were used to measure gene expression.

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Project description:WT mice and Nfkb/p65 S534A were exposed to 1µg/kg LPS and their gene expression measured. Affymetrix Mouse 1.0ST chips were used to measure gene expression

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Myeloid cell RelA/p65 promotes lung cancer proliferation

Project description:Smoking is the most important risk factor for both lung cancer (LC) and chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the role of myeloid cell NF-kB in the regulation of tumor cell growth signaling. We subjected mice lacking myeloid RelA/p65 to a metastatic LC model. Cigarette smoke (CS) exposure significantly increased the proliferation of Lewis lung carcinoma cell (LLC) tumors in wild type mice. In CS exposed mice lacking myeloid RelA/p65, the tumor growth was largely inhibited. Transcriptome and pathway analysis of cancer tissue revealed a fundamental impact of myeloid cells on various growth signaling pathways. Myeloid RelA/p65 is necessary to link smoke-induced inflammation with LC growth. Keywords: Expression profiling by array Analysis of gene expression in lewis lung carcinoma cells resected from lungs of WT and RelA/p65 deficient mice exposed to smoke or air. Four different samples were analyzed (3 replicates each).

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RNase A treatment increases the recruitment of p65 to DNA

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Myeloid cell RelA/p65 promotes lung cancer proliferation

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p65

Project description:p65

| PRJNA811604 | ENA