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Gene expression based profiling of tumor and mediastinal and hilar lymph nodes in NSCLC

ABSTRACT: Gene expression based profiling of tumor and mediastinal and hilar lymph nodes in NSCLC

PROVIDER: PRJNA812895 | ENA |

REPOSITORIES: ENA

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Gene expression variation in mediastinal (pulmonary-draining) lymph nodes of heaves-affected horses versus controls

Project description:We undertook gene expression microarray experiments to identify genes that are differentially expressed in heaves-affected horses versus matched controls. Mediastinal (pulmonary-draining) lymph nodes were sterilely obtained from affected and control horses, dissected, and frozen at -80oC. RNA was extracted from these tissues for downstream applications. These experiments utilized a commercially available Agilent horse array that featured >43,000 probes on a 4x44k array format. Mediastinal lymph node RNA from seven heaves-affected horses was compared to matching RNA from healthy, normal control horses.

2016-09-01 | E-GEOD-72645 | biostudies-arrayexpress

Expression data from mediastinal lymph nodes and blood samples of piglets experimentally infected with PCV2

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Genome-wide expression profiling of mediastinal lymph nodal metastasis of stage IIIA NSCLC patients before neoadjuvant chemotherapy

Project description:Non–small-cell lung cancer (NSCLC) is the leading cause of cancer deaths worldwide due to late diagnosis and lack of effective therapies to treat metastatic disease. About one third of NSCLC patients present at diagnosis with locally advanced cancer (stage IIIA) which metastasizes ipsilateral mediastinal or subcarinal lymph nodes (N2). Neoadjuvant chemotherapy (NACT) followed by surgery is the treatment of choice for resectable N2 disease. However, the majority of patients do not respond to NACT and show persistent lymph nodal metastases and an adverse outcome. Our scant knowledge of the molecular biology of lymph node metastases (LNmets) represents a major obstacle to develop more effective therapies. Here, we investigated gene expression profile (coding and non-coding) of LNmets collected by endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) and mediastinoscopy, in two cohorts of stage IIIA patients before NACT (N=70). We discovered a microRNA expression signature in LNmets predictive of NACT response of N2 patients. Importantly, we unveiled a miR-455-5p/PD-L1 regulatory axis which drives chemotherapy resistance and impact T cell viability in NSCLC. Our data suggests the relevance of LNmets molecular profiling to predict response to NACT likewise presents strong evidences of a miRNA-based mechanism which functionally links chemotherapy response with PD-L1 regulation.

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Gene expression variation in mediastinal (pulmonary-draining) lymph nodes of heaves-affected horses versus controls

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Gene expression based profiling of tumor and mediastinal and hilar lymph nodes in NSCLC

Project description:Individualized outcome prediction classifiers were successfully constructed through expression profiling of a total of 770 genes in 16 surgically-trested non-small cell lung cancer (NSCLC) cases with a focus on immune exhaustion

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RNA sequencing of zbtb46+ conventional dendritic cells in the mediastinal lymph nodes of naïve and previously influenza infected memory mice

Project description:Purpose: The goal of this study was to compare the transcriptome of conventional dendritic cells (cDC) isolated from the mediastinal lymph nodes (medLN) of mice that were uninfected (naïve) or had been infected 25 days previously with X31 (memory) Methods: medLN cDC were isolated from naïve and memory mice in biological triplicates and RNA was sequenced using Illumina Novaseq 6000. Reads were mapped to mouse genome using Kallisto and differential gene expression determined by DESeq2 Results: 61 differentially expressed genes were found between naive and memory medLN cDC after a workflow that filtered out the bottom third of genes by number of reads and had a padj ≤0.05 and fold change ≥2.

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scRNAseq of stromal cells isolated from mesenteric lymph nodes (MLN), peripheral lymph nodes (PLN) and mandibular lymph nodes (mandLN)

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scRNAseq of stromal cells isolated from mesenteric lymph nodes (MLN), peripheral lymph nodes (PLN) and mandibular lymph nodes (mandLN)

Project description:scRNAseq of stromal cells isolated from mesenteric lymph nodes (MLN), peripheral lymph nodes (PLN) and mandibular lymph nodes (mandLN)

| PRJEB52336 | ENA

Microarray analysis of mediastinal lymph node of pigs naturally affected by postweaning multisystemic wasting syndrome

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Genome-wide expression profiling of mediastinal lymph nodal metastasis of stage IIIA NSCLC patients before neoadjuvant chemotherapy

Project description:Genome-wide expression profiling of mediastinal lymph nodal metastasis of stage IIIA NSCLC patients before neoadjuvant chemotherapy

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