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Pancreatic cancer cells upregulation of LPA receptor 4 in response to stress create a tumor-initiating niche

ABSTRACT: Pancreatic cancer cells upregulation of LPA receptor 4 in response to stress create a tumor-initiating niche

PROVIDER: PRJNA813316 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18249101_1.fastq.gz	Fastqsanger.gz
	SRR18249101_2.fastq.gz	Fastqsanger.gz
	SRR18249102_1.fastq.gz	Fastqsanger.gz
	SRR18249102_2.fastq.gz	Fastqsanger.gz
	SRR18249103_1.fastq.gz	Fastqsanger.gz

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Pancreatic cancer cells upregulation of LPA receptor 4 in response to stress create a tumor-initiating niche

Project description:We report that the lysophosphatidic acid receptor 4 (LPAR4) is specifically upregulated on cells exposed to environmental stress or cancer drugs where it promotes stress tolerance, self-renewal, and tumor initiation. We find that ectopic LPAR4-expressing tumors display an enrichment of key extracellular matrix (ECM)-related genes that are established drivers of cancer stemness, and surprisingly do not require stimulation with the canonical LPAR4 ligand, LPA. From this RNAseq data, we observed that LPAR4 promotes a subset of genes, mainly extracellular matrix related genes, independent of its ligand LPA in patient-derived xenograft cells.

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Gene expression in glucose-grown L-pipecolic acid production strains C.glutamicum LPA-1A and LPA-5 compared to the non-L-pipecolic acid-producing strain C. glutamicum LPA-0 [2]

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Project description:The endometrium plays a crucial role in the reproductive organs in the aspect of embryo-maternal communication and pregnancy. This study investigated transcriptome profiles of endometrial cells stimulated with PBS, LPA and LPA in combination with IFNt. LPA, one of the signaling molecule, is locally produced and released from the bovine endometrium during estrous cycle and early pregnancy. The highest concentration of LPA and expression of its active receptor (LPAR1) were detected in bovine endometrium at the time of maternal recognition of pregnancy, when the conceptus announces its presence by increased IFNt production. Using transcriptomic approach we compared the influence of LPA and LPA together with IFNt on the gene expression profiles in bovine endometrial cells. A total of nine normally cycling Holstein/Polish Black and White (75/25% respectively) cows were used in this study. Global transcriptional profiling was performed using co-cultured stromal and epithelial cells (ratio - 3:1) isolated from bovine endometrium. Three experimental conditions (control (PBS), LPA and LPA plus IFNt) with three replicates per condition were prepared. Total RNAs were extracted from 9 pooled samples (n=3 for each sample) amplified and hybridized onto Affymetrix microarrays.

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