Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression [miRNA-seq]

ABSTRACT: ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression [miRNA-seq]

PROVIDER: PRJNA814267 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18280224.fastq.gz	Fastqsanger.gz
	SRR18280225.fastq.gz	Fastqsanger.gz
	SRR18280226.fastq.gz	Fastqsanger.gz
	SRR18280227.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression

Project description:ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression

| PRJNA814271 | ENA

ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression [miRNA-seq]

Project description:To better understand the regulatory roles of ApoE in neurogenesis, we differentiated isogenic control and ApoE-/- human neural stem cells (NSC) into mature cortical neurons and cultured them for additional three weeks. In this study, we found that ApoE is only expressed in control NSC and neural progenitor cell (NPC) stages, but not in mature neurons, suggesting that ApoE may epigenetically regulate the integrity and maintenance of the mature neurons. Mechanistic studies revealed that absence of ApoE in NSC led to upregulation of certain microRNAs, including miR-199a-5p. These microRNAs targeted EZH1 to reduce its protein expression, resulting in the lower level of repressive H3K27me3 marks in ApoE-/- NPC and mature neurons. Chromatin immunoprecipitation experiments suggests that the lower level of H3K27me3 at various extracellular matrix organization and angiogenesis genes is responsible for their higher expression and aberrant phenotypes observed in ApoE-/- neurons. Taken together, our results indicate that ApoE maintains pure population of mature neurons via H3K27me3-mediated repression of genes that drive non-neuronal cell proliferation in NPC stage.

2024-01-29 | GSE198230 | GEO

ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression [RNA-seq]

Project description:ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression [RNA-seq]

| PRJNA814246 | ENA

ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression [RNA-seq]

2024-01-29 | GSE198228 | GEO

ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-01-29 | GSE198245 | GEO

Autophagy maintains intestinal stem cell integrity

Project description:Autophagy maintains intestinal stem cell integrity

| PRJNA564106 | ENA

Atr maintains chromosomal integrity during postnatal cerebellar neurogenesis

Project description:Atr maintains chromosomal integrity during postnatal cerebellar neurogenesis

| PRJNA338316 | ENA

Hormone-responsive Bmpr1a maintains myoepithelial integrity during pregnancy

Project description:Hormone-responsive Bmpr1a maintains myoepithelial integrity during pregnancy

| PRJNA691166 | ENA

BRCA1 maintains telomere integrity through suppression of TERRA RNA and TERRA R-loop-induced DNA damage

Project description:Data in support of Vohhodina et al. "BRCA1 maintains telomere integrity through suppression of TERRA RNA and TERRA R-loop-induced DNA damage"

2021-04-21 | MSV000087276 | MassIVE

DNA methylation maintains integrity of higher order genome architecture

Project description:DNA methylation maintains integrity of higher order genome architecture

| PRJNA663616 | ENA