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RNA sequencing analysis of mouse kidney fibroblasts isolated from control kidneys or UUO surgery operated kidneys

ABSTRACT: RNA sequencing analysis of mouse kidney fibroblasts isolated from control kidneys or UUO surgery operated kidneys

PROVIDER: PRJNA817103 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18356123_1.fastq.gz	Fastqsanger.gz
	SRR18356123_2.fastq.gz	Fastqsanger.gz
	SRR18356124_1.fastq.gz	Fastqsanger.gz
	SRR18356124_2.fastq.gz	Fastqsanger.gz
	SRR18356125_1.fastq.gz	Fastqsanger.gz

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RNA sequencing analysis of mouse kidney fibroblasts isolated from control kidneys or UUO surgery operated kidneys

Project description:RNA sequencing of fibroblasts isolated from mouse kidneys which were either subjected to left ureter obstruction (UUO) or non obstructed (Control) conditions

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RNA sequencing of normal and unilateral ureteral obstruction (UUO) operated mouse kidneys

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RNA sequencing of normal and unilateral ureteral obstruction (UUO) operated mouse kidneys

Project description:RNA sequencing of normal and unilateral ureteral obstruction (UUO) operated mouse kidneys

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UUO-rUUO small RNA seq, Denby lab 2019

Project description:Small RNA sequencing of sorted cell type, mice kidneys, after unilateral ureteral obstructive (UUO) surgery after 2 days, 7 days and a reversible (rUUO) 14 day model with corresponding sham operated mice. The goal of the study is to identify micro-RNA dysregulation of expression between different cell types corresponding with kidney injury, in order to identify and assess biomarkers which could be translated into the clinical setting.

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UUO-rUUO single population RNA seq, Denby lab 2019

Project description:RNA sequencing of sorted cell types, isolated from mice kidneys, after unilateral ureteral obstructive (UUO) surgery after 2 days, 7 days and a reversible (rUUO) 14 day model with corresponding sham operated mice. The goal of the study was to identify temporal gene expression changes in different cell types corresponding with kidney injury, in order to understand cell specific transcriptomic changes in the context of kidney injury and repair.

2025-03-27 | GSE262799 | GEO

Proteomic profiling in mouse kidneys post-UUO

Project description:Increased export of transglutaminase-2 (TG2) by tubular epithelial cells (TECs) into the surrounding interstitium modifies the extracellular homeostatic balance leading to fibrotic membrane expansion. Although silencing of extracellular TG2 ameliorates progressive kidney scarring in animal models of chronic kidney disease, the pathway through which TG2 is secreted from TECs and contributes to disease progression has not been elucidated. In this study, we developed a global proteomic approach to identify binding partners of TG2 responsible for TG2 externalization in kidneys subjected to unilateral ureteric obstruction, using TG2-knockout kidneys as negative controls. We report a robust and unbiased analysis of the membrane interactome of TG2 in fibrotic kidneys relative to the entire proteome post-UUO detected by SWATH-mass spectrometry.

2018-02-07 | PXD008173 | Pride

RNA sequencing of sham-operated and unilateral ureteral obstruction (UUO)-operated mouse kidneys in Pax8Cre+ and Kdm6afl/Y Pax8Cre+ knockout mice

Project description:RNA sequencing of sham-operated and unilateral ureteral obstruction (UUO)-operated mouse kidneys in Pax8Cre+ and Kdm6afl/Y Pax8Cre+ knockout mice

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2013-03-20 | E-GEOD-45304 | biostudies-arrayexpress

Mouse kidney tissue: Control vs. UUO

Project description:The mRNA transcriptome and m6A methylation microarray profiling of mouse kidney tissues. Kidney tissues from the sham-operated group and unilateral ureteral ligation/obstruction (UUO) kidney tissues were compared. The latter were mainly fibrotic kidney tissues. The goal was to identify the effect of the renal fibrosis on gene expression and corresponding m6A modifications during kidney fibrosis.

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