Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genomic data archive from the Network for Pancreatic Organ donors with Diabetes

ABSTRACT: Genomic data archive from the Network for Pancreatic Organ donors with Diabetes

PROVIDER: PRJNA821969 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Genomic data archive from the Network for Pancreatic Organ donors with Diabetes

Project description:Genomic data archive from the Network for Pancreatic Organ donors with Diabetes

| PRJNA821970 | ENA

Transcriptional analysis of islets of Langerhans from organ donors of different ages

Project description:Islet function diminishes with age and as such the incidence of type 2 diabetes increases. The cause of this is unknown. In this study whole islets were extracted with laser capture microdissection from organ donors 1-81 years of age. Increasing age was associated with a downregulation of pathways associated with the cell cycle and increase in markers of senescence e.g. CDKN2A. Among novel genes increasing with age was SPP1.

2021-02-18 | GSE165121 | GEO

Homo sapiens

Project description:Network for Pancreatic Organ Donors with Diabetes (nPOD)

| PRJNA662928 | ENA

Affymetrix profiling of IMIDIA biobank samples from organ donors and partially pancreatectomized patients [organ donor cohort]

Project description:Pancreatic islet beta cell failure causes type 2 diabetes (T2D). The IMIDIA consortium has used a strategy entailing a stringent comparative transcriptomics analysis of islets isolated enzymatically or by laser microdissection from two large cohorts of non-diabetic (ND) and T2D organ donors (OD) or partially pancreatectomized patients (PPP). This work led to the identification of a signature of genes that were differentially expressed between T2D and ND regardless of the sample type (OD or PPP). This signature includes 19 genes, of which 9 have never been previously reported to be differentially expressed in T2D islets. The PPP cohort also includes samples from individuals with impaired glucose tolerance (IGT) or recent onset diabetes associated with a pancreatic exocrine disorder (T3cD). Notably, none of the 19 signature genes of T2D islets were significantly dysregulated in islets of subjects with IGT or T3cD, suggesting that their changed expression reflects beta cell deterioration rather than a deficit preceding it.

2017-12-09 | GSE76894 | GEO

Single-cell RNA-sequencing of adult human prostates from organ donors

Project description:Single-cell RNA-sequencing was conducted on heterogeneous human prostates FACS sorted for viability from organ donors (with no known prostatic diseases) on the 10x Genomics platform.

2020-04-28 | GSE145843 | GEO

Single-cell RNA-sequencing of adult human prostates from organ donors v2

2021-07-07 | GSE172316 | GEO

Single cell RNA-seq of human pancreatic endocrine cells from Juvenile, adult control and type 2 diabetic donors.

2016-07-05 | GSE83139 | GEO

Single cell RNA-seq of human pancreatic endocrine cells from Juvenile, adult control and type 2 diabetic donors.

Project description:We successfully sequenced and annotated more than 400 cells from child, adult control, type 1 diabetes and type 2 diabetes donors. We detect donor-type specific transcript variation. We also report that cells from child donors have less defined gene signature. Cells from type 2 diabetes donors resemble juvenile cells in gene expression. Cells from three adult controls (56, 74, 92), one donor with type 1 diabetes (91), two donors with type 2 diabetes (75, 143), and two child donors (40, 72) were sequenced. Numbers in parathesis indicates number of cells sequenced.

2016-07-05 | E-GEOD-83139 | biostudies-arrayexpress

Single-cell RNA-sequencing of adult human prostates from organ donors

Project description:Single-cell RNA-sequencing of adult human prostates from organ donors

| PRJNA608498 | ENA

Affymetrix profiling of IMIDIA biobank samples from organ donors and partially pancreatectomized patients [partially pancreatectomized patient cohort]

2017-12-09 | GSE76895 | GEO