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Regulation of human trophoblast gene expression by endogenous retroviruses [CUT&RUN]

ABSTRACT: Regulation of human trophoblast gene expression by endogenous retroviruses [CUT&RUN]

PROVIDER: PRJNA826508 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18745701_1.fastq.gz	Fastqsanger.gz
	SRR18745701_2.fastq.gz	Fastqsanger.gz
	SRR18745702_1.fastq.gz	Fastqsanger.gz
	SRR18745702_2.fastq.gz	Fastqsanger.gz
	SRR18745703_1.fastq.gz	Fastqsanger.gz

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Regulation of human trophoblast gene expression by endogenous retroviruses [CUT&TAG]

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Regulation of human trophoblast gene expression by endogenous retroviruses [CUT&RUN]

Project description:The placenta is a fast-evolving organ that displays large morphological and histological differences across eutherians, but the genetic changes driving placental evolution have not been fully elucidated. Transposable elements, through their capacity to quickly generate genetic variation and affect host gene regulation, may have helped to define species-specific trophoblast gene expression programmes. Here were assessed the contribution of transposable elements to human trophoblast gene expression by acting as enhancers or promoters. Using epigenomic data from primary trophoblast and human stem cell lines, we identified multiple endogenous retrovirus families with regulatory potential that lie close to genes with preferential trophoblast expression. These largely primate-specific elements are associated with inter-species gene expression differences, and are bound by transcription factors with key roles in placental development. Using genetic editing we demonstrated that several elements act as expression enhancers of important placental genes, such as CSF1R and PSG5. We also identified an LTR10A element that regulates ENG expression, affecting trophoblast migration and secretion of soluble ENG, with potential implications for preeclampsia. Our data show that transposons have made important contributions to human trophoblast gene regulation, and suggest that their activity may affect pregnancy outcomes.

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Regulation of human trophoblast gene expression by endogenous retroviruses

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Regulation of human trophoblast gene expression by endogenous retroviruses [ChIP-seq]

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Cut and run analysis in human trophoblast stem cells (CT27) upon pulling down with GATA2 and GATA3 antibody

Project description:GATA transcription factors, particularly GATA2 and GATA3 are selectively expressed in the extraembryonic trophoblast lineage and regulates gene expression to promote trophoblast self-renewal during mammalian development. However, we have a poor understanding about the contribution of these GATA factors, in the process of syncytiotrophoblast (SynT) development. Thus, the goal of this study is to define the importance of GATA2 and GATA3 in orchestrating a global gene expression program that poises and commits mammalian trophoblast stem cells to the SynT lineage. Using the cut and run technique for GATA2 and GATA3 antibodies in the human trophoblast stem cells we are aiming to identify the direct targets of the GATA transcription factors that are essential for determining the SynT lineage. Three individual experiments were performed.

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