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Characterization of mast cells from human umbilical cord blood

ABSTRACT: Characterization of mast cells from human umbilical cord blood

PROVIDER: PRJNA831842 | ENA |

REPOSITORIES: ENA

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Characterization of mast cells from human umbilical cord blood

Project description:Mast cells are tissue-resident innate immune cells that express high affinity to receptor immunoglobulin E and responsible for host defense and array of diseases relate to immune system. We aim to characterize the function of human umbilical cord blood-dervied mast cells (hCBMCs).

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Effects of IL-4 conditioning on human umbilical cord blood-derived mast cells

Project description:This study evaluates the effects of 96h stimulus with Interleukin 4 (100 ng/mL) on the transcriptome of human umbilical cord blood derived mast cells. Through this approach, we identify upregulation of key intraepithelial mast cell-associated transcripts and downregulation of subepithelial mast cell-associated transcripts. Replicates are technical duplicates. Samples were sequenced on an Illumina NextSeq 500.

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Transcription profiling of human umbilical cord blood derived mast cells IgE sensitized followed by crosslinking receptor at different time points

Project description:Human umbilical cord blood derived mast cells IgE sensitized followed by crosslinking receptor at different time points

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Effects of IL-4 conditioning on human umbilical cord blood-derived mast cells

Project description:Effects of IL-4 conditioning on human umbilical cord blood-derived mast cells

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Transcriptomic profiling of 27-year cryopreserved umbilical cord blood HSCs/HPCs

Project description:Umbilical cord blood banking is critical for the success of umbilical cord blood transplants. Here we analyzed transcriptomic differences between 27-year cryopreserved umbilical cord blood hematopoietic stem cells (HSCs) and multipotent progenitor cells (MPPs) and those derived from fresh cord blood. We also leveraged differences in engraftment capacity to examine the transcriptomes of HSCs/HPCs defined by engraftment capacity, demonstrating the feasibility of this approach for identifying potency markers to aid in the selection of cord blood units for transplantation and revealing novel potential regulators of cord blood HSC/HPC engraftment.

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Mast Cell_time series

Project description:Human umbilical cord blood derived mast cells IgE sensitized followed by crosslinking receptor at different time points Keywords: time-course

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Microarray comparison of adult peripheral blood megakaryocytes to umbilical cord blood-derived megakaryocytes

Project description:Primary adult peripheral blood (PB) megakaryocytes and umbilical cord blood (CB) megakaryocytes

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Human umbilical cord blood-derived mesenchymal stem cells from 2 donors

Project description:screening of signature deterimes the individual variations in the therapeutic efficacy of human umbilical cord blood-derived mesenchymal stem cells There is paucity of information whether human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) from separate donors might have different effects on improving myocardial repair after myocardial infarction (MI).

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Expression data from umbilical cord blood and peripheral blood stem cell-derived monocytes of human

Project description:To identify the differences between human umbilical cord blood and peripheral blood monocytes, we performed unsupervised bioinformatic analyses by microarrays.

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