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Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [CML exposed MDAMB231 cells]

ABSTRACT: Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [CML exposed MDAMB231 cells]

PROVIDER: PRJNA836636 | ENA |

REPOSITORIES: ENA

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Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [CML exposed MDAMB231 cells]

Project description:Diabetes commonly affects cancer patients. As a comorbidity, it may modify tumor biology and therapy response. Yet, we still lack an understanding of the diabetes-induced molecular changes in human breast tumors and their implication for therapy. The goal of this study was aimed to identify diabetes induced phenotypes and molecular signatures in breast cancer. Here, we investigated the effect of diabetes on breast cancer biology using a three-pronged approach that included analysis of orthotopic human tumor xenografts, patient tumors, and breast cancer cells exposed to diabetes and hyperglycemia. Diabetes and hyperglycemia induced a mesenchymal and stem cell-like phenotypes. Further Diabetes and hyperglycemia also associated with oxidative stress and both gene expression and mutational signatures of DNA repair deficiency. Breast cancer cells cultured under hyperglycemia acquired increased DNA damage and sensitivity to DNA damage response inhibitors. Based on these observations, diabetes-associated breast tumors may show an increased drug response to DNA repair pathway inhibitors that are cancer therapeutics.

2023-11-07 | GSE202597 | GEO

Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency

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Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [Xenografts]

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Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [Breast Tumors]

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Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [RNAseq-Hs578T]

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Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [MDAMB157 cell lines]

Project description:Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [MDAMB157 cell lines]

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Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [ER positive cell lines]

Project description:Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [ER positive cell lines]

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Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [RNAseq-MDA-MB-231_and_MDA-MB-468]

Project description:Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [RNAseq-MDA-MB-231_and_MDA-MB-468]

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Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-11-07 | GSE202923 | GEO

Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [Xenografts]

2023-11-07 | GSE202599 | GEO