Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ChIP-Seq in Wild Type (WT), and NM1-knockout (KO) Mouse Embryonic Fibroblasts

ABSTRACT: ChIP-Seq in Wild Type (WT), and NM1-knockout (KO) Mouse Embryonic Fibroblasts

PROVIDER: PRJNA837099 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

ChIP-Seq in Wild Type (WT), and NM1-knockout (KO) Mouse Embryonic Fibroblasts

Project description:Genome-wide ChIP-Seq of various epigenetic marks in WT and NM1-KO MEFs

2022-08-25 | GSE202716 | GEO

ATAC-Seq analysis of wild-type and nm1-knockout mouse embryonic fibroblasts

Project description:ATAC-Seq of wild-type and nm1-knockout mouse embryonic fibroblasts to investigate the impact of nm1 loss on chromatin accessibility

2022-08-25 | GSE198988 | GEO

Hi-C sequencing analysis of wild-type and nm1-knockout mouse embryonic fibroblasts

Project description:Hi-C sequencing of wild-type and nm1-knockout mouse embryonic fibroblasts to investigate the impact of nm1 loss on genome architecture

2022-08-25 | GSE198989 | GEO

Wild-type and nm1-knockout mouse embryonic fibroblasts

Project description:Wild-type and nm1-knockout mouse embryonic fibroblasts

| PRJNA817636 | ENA

Expression profiling of NM1 KO and WT mice

Project description:Plasma membrane tension is an important feature that determines the cell shape and influences processes such as cell motility, spreading, endocytosis and exocytosis. Unconventional class 1 myosins are potent regulators of plasma membrane tension because they physically link the plasma membrane with the adjacent cytoskeleton. We identified nuclear myosin 1 (NM1) - a putative nuclear isoform of myosin 1c (Myo1c) - as a new player in the field. Although having specific nuclear function, we show that NM1 localizes preferentially to the plasma membrane. Deletion of NM1 causes more than 50% increase in the elasticity of the plasma membrane around the actin cytoskeleton as measured by atomic force microscopy. This higher elasticity of NM1 knock-out cells leads to 25% higher resistance to short-term hypotonic environment and rapid cell swelling. In contrary, overexpression of NM1 in WT cells leads to additional 30% reduction of their survival. We have brought evidence that NM1 has a direct functional role in the cytoplasm as a dynamic linker between the cell membrane and the underlying cytoskeleton, regulating the degree of effective plasma membrane tension. We used tissues from NM1 WT and KO mice with highest expression of NM1, lungs and heart (3 replicates each) and skin fibroblast derived from each mice (2 replicates each)

2015-12-05 | E-GEOD-75709 | biostudies-arrayexpress

ATAC-Seq analysis of wild-type and nm1-knockout mouse embryonic fibroblasts

Project description:ATAC-Seq analysis of wild-type and nm1-knockout mouse embryonic fibroblasts

| PRJNA817667 | ENA

Expression profiling of NM1 KO and WT mice

2015-12-05 | GSE75709 | GEO

Hi-C sequencing analysis of wild-type and nm1-knockout mouse embryonic fibroblasts

Project description:Hi-C sequencing analysis of wild-type and nm1-knockout mouse embryonic fibroblasts

| PRJNA817666 | ENA

WT, LKB1 KO, and LKB1/CRTC2 KO mouse embryonic fibroblasts

Project description:WT, LKB1 KO, and LKB1/CRTC2 KO mouse embryonic fibroblasts

| PRJNA887178 | ENA

RNA-seq profiling of WT, LKB1 KO, and LKB1/CRTC2 KO mouse embryonic fibroblasts

Project description:Investigating transcriptional profile of WT, LKB1 KO, and LKB1/CRTC2 KO mouse embryonic fibroblasts untreated or stimulated with IL-1β

2023-05-11 | GSE214823 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data