Project description:The goal of the experiment was to explore the differences in the proteomic landscape of pancreatic cancer tissues collected by the Rapid Autopsy Program at UNMC. We hypothesized the proteomic profile can reflect some of the clinical features observed in the patient, and such information can be used for the diagnosis of the disease, or assisting in the selection of treatment options in a clinical setting. The liver metastases tissue collected from 59 pancreatic cancer patients were used to explore the proteomic landscape. 56 of these patients were diagnosed with pancreatic ductal adenocarcinoma (PDAC) and 3 of them had pancreatic neuroendocrine tumors (PanNET).

2019-11-18 | PXD012173 | Pride

Ventriculomics analyses of autopsy AD tissue

Project description:Very little studies have explored the role played by the specialized choroid plexus epithelial cells and the ependymal cells that line the ventricles. In normal and pathological (AD) ageing, reports of alterations in the blood brain CSF barrier (BCSFB) integrity and membrane transporters, accompanied by deficiencies in CSF production and an enlarged ventricular volume have been documented. The molecular sequelae of events driving these age-related pathological changes remains elusive. Given the pivotal role of the ventricular system in normal brain physiology, in this study we proposed to explore their contributing role towards AD pathogenesis. To address this, we used our state-of-the-art proteomic platform, a liquid chromatography/mass spectrometry (LC-MS) approach coupled with Tandem Mass Tag labeling technology to conduct a detailed characterization and assessment of molecular changes in protein expression levels from isolated tissue from the walls of the ventricles in autopsy AD cases, and two groups of age-matched control cases (non-agenarian’s with no AD pathology, and those with no clinical AD diagnosis but significant amyloid pathology and Braak staging).

2021-09-08 | PXD012059 | Pride

Novel temporal and spatial patterns of metastatic colonization from breast cancer rapid-autopsy tumor biopsies

Project description:Novel temporal and spatial patterns of metastatic colonization from breast cancer rapid-autopsy tumor biopsies

| PRJNA765932 | ENA

Tumor heterogeneity and acquired drug resistance in FGFR2 fusion-positive cholangiocarcinoma through rapid research autopsy

Project description:Tumor heterogeneity and acquired drug resistance in FGFR2 fusion-positive cholangiocarcinoma through rapid research autopsy

| PRJNA544351 | ENA

Tumor heterogeneity and acquired drug resistance in FGFR2 fusion-positive cholangiocarcinoma through rapid research autopsy

Project description:Tumor heterogeneity and acquired drug resistance in FGFR2 fusion-positive cholangiocarcinoma through rapid research autopsy

| PRJNA544352 | ENA

PICU cases

Project description:PICU cases