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Transcripotome analysis of platelet-rich plasma microneedles promoting hair regrowth in mice skin

ABSTRACT: Transcripotome analysis of platelet-rich plasma microneedles promoting hair regrowth in mice skin

PROVIDER: PRJNA842652 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19415736_1.fastq.gz	Fastqsanger.gz
	SRR19415736_2.fastq.gz	Fastqsanger.gz
	SRR19415737_1.fastq.gz	Fastqsanger.gz
	SRR19415737_2.fastq.gz	Fastqsanger.gz
	SRR19415738_1.fastq.gz	Fastqsanger.gz

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Transcripotome analysis of platelet-rich plasma microneedles promoting hair regrowth in mice skin

Project description:To fully interrogate mechanism of the platelet-rich plasma microneedles(PRP-MNs) in promoting hair regrowth in mice skin, we sought to perform a thorough and comprehensive transcripotome profiling of PRP-MNs,platelet-rich plasma(PRP) and microneedles(MNs) treatments of mice skin, with nective control(NC).

2023-07-01 | GSE204878 | GEO

Gene expression profiles of human immature dendritic cells and macrophages after 6h of co-cultivation with Aspergillus fumigatus and platelet rich plasma

Project description:In a whole-transcriptome study, cellular responses of DCs and macrophages confronted with the fungi A. fumigatus, platelet rich plasma (PRP) or the combination of A.fumigatus and PRP were investigated. Therefore DCs and macrophages of three independent donors were harvested after 6 hours co-culture with A. fumigatus, platelet rich plasma (PRP) or the combination of A.fumigatus and PRP and analyzed with Affymetrix whole genome expression arrays. In general, transcriptomic analysis revealed a cell type dependent clustering. Only little effects were obeserved by addition of PRP. Furthermore a clustering of A.fumigatus stimulated cells whether PRP was present or not, was observed. However, significant differences in the immune response of A.fumigauts stimuled DC and macrophages were determined.

2016-12-20 | GSE84921 | GEO

Platelet-rich plasma in young and elderly human exhibit a different proteomic profile

Project description:we prepared platelet-rich plasma from the blood of 6 young volunteers and 6 elderly volunteers, respectively, and removed 95% of high-abundance proteins, followed by mass spectrometry analysis.

2023-09-28 | PXD045750 |

Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis

Project description:In this study, in order to explore the role of autophagy of human hair follicle stem cells in hair growth, we explored new ideas for hair regrowth. In this study, rapamycin was used to treat hair follicle stem cells to promote autophagy, and the different expression of genes was observed by comparing with the blank control group.

2024-01-10 | GSE229890 | GEO

Mass spectrometry data of Platelet-rich plasma from 6 young and 6 elderly individuals

Project description:We prepared platelet-rich plasma from the blood of 6 young volunteers and 6 elderly volunteers, respectively, and removed 95% of high-abundance proteins, followed by mass spectrometry analysis.

2024-04-24 | PXD050061 | Pride

TMT-based Proteomic Analysis of Platelet-rich Plasma between Healthy Adults and Children.

Project description:Platelet rich plasma (PRP) is an autologous, plasma component that contains a supraphysiological concentration of platelets, leucocytes, growth factors, and other bioactive proteins such as cytokines and chemokines that can be delivered to the site of injury. In this study, we highlighted the differential composition of PRP between healthy children and adults by TMT-based quantitative proteomics.

2023-03-07 | PXD040639 |

Human platelet-rich plasma promotes the primordial follicle activation through the PI3K/Akt signaling pathway

Project description:The activation of dormant primordial follicles is a promising method for rescuing the infertility of aged women and premature ovarian insufficiency (POI) patients. Accumulating evidences in both human and animal suggest that human platelet-rich plasma (hPRP) has the ability to recover ovarian function and promote follicle growth, however the underlying mechanisms remain unclear. In the current study, we revealed that hPRP promoted the activation of primordial follicles and the proliferation of granulosa cells. hPRP treatments significantly increased the levels of phosphorylated protein kinase B (Akt) and forkhead Box O3a (FOXO3a), and the number of oocytes with FOXO3a nuclear export. The hPRP-induced primordial follicle activation could be blocked by LY294002, the inhibitor of PI3K/Akt. By in vivo injection newborn mice model and in vitro culture human ovarian fragments, hPRP was further proved to be effective in the activation of primordial follicles. Taken together, our results suggest that hPRP can promote the primordial follicle activation through the PI3K/Akt pathway. Our results provide a theoretical basis for the clinical application of hPRP in aged women and POI patients.

2024-09-01 | GSE263743 | GEO

Human platelet-rich plasma promotes the primordial follicle activation through the PI3K/Akt signaling pathway

Project description:Human platelet-rich plasma promotes the primordial follicle activation through the PI3K/Akt signaling pathway

| PRJNA1099148 | ENA

Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization.

Project description:BackgroundAutologous platelet-rich plasma (PRP) has been suggested to be effective for wound healing. However, evidence for its use in patients with acute and chronic wounds remains insufficient. The aims of this study were to comprehensively examine the effectiveness, synergy and possible mechanism of PRP-mediated improvement of acute skin wound repair.MethodsFull-thickness wounds were made on the back of C57/BL6 mice. PRP or saline solution as a control was administered to the wound area. Wound healing rate, local inflammation, angiogenesis, re-epithelialization and collagen deposition were measured at days 3, 5, 7 and 14 after skin injury. The biological character of epidermal stem cells (ESCs), which reflect the potential for re-epithelialization, was further evaluated in vitro and in vivo.ResultsPRP strongly improved skin wound healing, which was associated with regulation of local inflammation, enhancement of angiogenesis and re-epithelialization. PRP treatment significantly reduced the production of inflammatory cytokines interleukin-17A and interleukin-1β. An increase in the local vessel intensity and enhancement of re-epithelialization were also observed in animals with PRP administration and were associated with enhanced secretion of growth factors such as vascular endothelial growth factor and insulin-like growth factor-1. Moreover, PRP treatment ameliorated the survival and activated the migration and proliferation of primary cultured ESCs, and these effects were accompanied by the differentiation of ESCs into adult cells following the changes of CD49f and keratin 10 and keratin 14.ConclusionPRP improved skin wound healing by modulating inflammation and increasing angiogenesis and re-epithelialization. However, the underlying regulatory mechanism needs to be investigated in the future. Our data provide a preliminary theoretical foundation for the clinical administration of PRP in wound healing and skin regeneration.

| S-EPMC7427034 | biostudies-literature

Bald scalp retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells

Project description:Androgenetic alopecia (AGA) or common baldness results from a marked decrease in hair follicle size. This miniaturization may be related to loss of hair follicle stem or progenitor cells. To test this hypothesis, we analyzed bald and non-bald scalp from the same individuals for the presence of hair follicle stem and progenitor cells using flow cytometry to quantitate cells expressing CYTOKERATIN 15 (KRT15), CD200, CD34 and ALPHA-6-INTEGRIN (ITGA6). High levels of KRT15 expression correlated with stem cell properties of small cell size and quiescence. Cells with the highest level of KRT15 expression were maintained in bald scalp; however, distinct populations of CD200high ITGA6high cells and CD34-positive cells were markedly diminished. Consistent with a progenitor cell phenotype, the diminished populations localized closely to the stem-cell rich bulge area but were larger and more proliferative than the bulge stem cells. In functional assays, analogous CD200 high /Itga6 high cells from murine hair follicles were multipotent and generated new hair follicles in skin reconstitution assays. These findings suggest that a defect in stem cell activation plays a role in the pathogenesis of AGA. This SuperSeries is composed of the SubSeries listed below.

2011-01-12 | GSE21569 | GEO

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