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Lactiplantibacillus plantarum isolate:MUS gut

ABSTRACT: Lactiplantibacillus plantarum isolate:MUS gut Genome sequencing

PROVIDER: PRJNA843588 | ENA |

REPOSITORIES: ENA

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Differences between static supernatant-, static biofilm- and flow biofilm-cells of two Lactiplantibacillus plantarum strains.

Project description:This study was conducted to analyze phenotypic and proteomic differences of two Lactiplantibacillus plantarum strains (WCFS1, model strain from human saliva, and CIP104448, stool isolate) when a biofilm was produced under static conditions (well researched), or with the addition of flow (novel).

2024-06-03 | PXD047751 | Pride

Extracellular vesicles of Lactiplantibacillus plantarum PCM 2675

Project description:Identification of proteins contained in extracellular vesicles of Lactiplantibacillus plantarum PCM 2675. Dataset is related to publication http://dx.doi.org/10.20517/evcna.2024.49. This work was financially supported by the National Science Centre, Poland (no. 2021/43/D/NZ6/01464).

2024-11-07 | PXD048874 | Pride

Survey of microbiota composition differences between obese subjects before and after Lactiplantibacillus plantarum probiotic treatment

Project description:The study evaluates the effect of Lactiplantibacillus plantarum IMC 510® supplementation on anthropometric and biochemical parameters, GM composition and gastrointestinal and general symptoms of overweight/obese subjects.

2023-05-03 | GSE222755 | GEO

LACTIPLANTIBACILLUS PLANTARUM STRENGTHENS THE INTESTINAL BARRIER: INVOLVEMENT OF THE ENDOCANNABINOIDOME

Project description:Probiotics have been suggested to ameliorate the function of the intestinal epithelial barrier and so have several mediators and receptors of the expanded endocannabinoid system, the endocannabinoidome (eCBome). Here we cocultured three live strains of Lactiplantibacillus plantarum with intestinal epithelial organoids to study their effects on the gut barrier function and the possible involvement of the eCBome in this effect. All three L.plantarum strains variously reduced the trans-epithelial permeability of intestinal organoids and promoted increased mRNA expression of several tight junction proteins and intestinal barrier proteins. Concomitantly, the three strains upregulated the expression of genes encoding biosynthetic enzymes (i.e., NapePLD, Abdh4, Gde1, Daglb) and receptors (i.e., Cnr1, Cnr2, Gpr55, and Ppara), while concurrently downregulating the expression of two essential catabolic enzymes (i.e. Faah and Naaa), involved in the signaling of several eCBome mediators known for their role in regulating the intestinal epithelial barrier. Selective inhibitors of eCBome mediator degrading enzymes FAAH and MAGL, i.e., URB597 and JZL184, increased N-acyl-ethanolamine (NAE) and 2-monoacylglycerol (2-MAG) levels, respectively, enhanced the expression of intestinal epithelial barrier genes and reduced the trans-epithelial permeability of organoids, as for L. plantarum strains. Interestingly, inflammation-induced trans-epithelial permeability in organoids was also reversed by both FAAH and MAGL inhibitors. We surmise that elevated endogenous levels of either NAEs or 2-MAGs promote improvement in small intestine trans-epithelial permeability and that L. plantarum strains may exploit this mechanism to promote these beneficial effects.

2025-01-31 | GSE263720 | GEO

Lactiplantibacillus plantarum isolate:AG20

Project description:Lactiplantibacillus plantarum isolate:AG20 Genome sequencing

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Project description:Lactiplantibacillus plantarum isolate:PM8 Genome sequencing

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The commensal bacterium Lactiplantibacillus plantarum imprints innate memory-like responses in mononuclear phagocytes

Project description:Gut microbiota is a constant source of antigens and stimuli to which the resident immune system has developed tolerance. However, the mechanisms by which mononuclear phagocytes, specifically monocytes/macrophages, cope with these usually pro-inflammatory signals is poorly understood. Here, we show that innate immune memory promotes anti-inflammatory homeostasis using as a model strains of the commensal bacterium, Lactiplantibacillus plantarum. Priming of monocytes/macrophages with bacteria, especially in its live form, enhances bacterial intracellular survival and decreases the release of pro-inflammatory signals to the environment, with lower production of TNF and higher levels of IL-10. Analysis of the transcriptomic landscape of these cells shows downregulation of pathways associated with the production of reactive oxygen species (ROS) and the release of cytokines, chemokines and antimicrobial peptides. Indeed, the induction of ROS prevents memory-induced bacterial survival. In addition, there is a dysregulation in gene expression of several metabolic pathways leading to decreased glycolytic and respiratory rates in memory cells. These data support commensal microbe-specific metabolic changes in innate immune memory cells that might contribute to homeostasis in the gut.

2021-07-06 | GSE159496 | GEO

Lactiplantibacillus plantarum isolate:UTNGt2

Project description:Lactiplantibacillus plantarum isolate:UTNGt2 Genome sequencing and assembly

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Lactiplantibacillus plantarum isolate:paper mulberry

Project description:Lactiplantibacillus plantarum isolate:paper mulberry Genome sequencing

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Lactiplantibacillus plantarum as a novel platform for production and purification of integral membrane proteins using RseP as the benchmark

Project description:Identification of gel bands from purified fractions from expression of RseP in E.coli and Lactiplantibacillus plantarum.

2023-06-02 | MSV000092087 | MassIVE