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Single-cell transcriptome analysis of the in-vivo response to viral infection in the cave nectar bat Eonycteris spelaea [scRNA-seq]

ABSTRACT: Single-cell transcriptome analysis of the in-vivo response to viral infection in the cave nectar bat Eonycteris spelaea [scRNA-seq]

PROVIDER: PRJNA847556 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19599579_1.fastq.gz	Fastqsanger.gz
	SRR19599579_2.fastq.gz	Fastqsanger.gz
	SRR19599580_1.fastq.gz	Fastqsanger.gz
	SRR19599580_2.fastq.gz	Fastqsanger.gz
	SRR19599581_1.fastq.gz	Fastqsanger.gz

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Single-cell transcriptome analysis of the in-vivo response to viral infection in the cave nectar bat Eonycteris spelaea

Project description:Single-cell transcriptome analysis of the in-vivo response to viral infection in the cave nectar bat Eonycteris spelaea

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Single-cell transcriptome analysis of the in-vivo response to viral infection in the cave nectar bat Eonycteris spelaea [Bulk RNA-seq]

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Exploring the genome and transcriptome of the cave nectar bat Eonycteris spelaea with PacBio long-read sequencing.

Project description:BackgroundIn the past two decades, bats have emerged as an important model system to study host-pathogen interactions. More recently, it has been shown that bats may also serve as a new and excellent model to study aging, inflammation, and cancer, among other important biological processes. The cave nectar bat or lesser dawn bat (Eonycteris spelaea) is known to be a reservoir for several viruses and intracellular bacteria. It is widely distributed throughout the tropics and subtropics from India to Southeast Asia and pollinates several plant species, including the culturally and economically important durian in the region. Here, we report the whole-genome and transcriptome sequencing, followed by subsequent de novo assembly, of the E. spelaea genome solely using the Pacific Biosciences (PacBio) long-read sequencing platform.FindingsThe newly assembled E. spelaea genome is 1.97 Gb in length and consists of 4,470 sequences with a contig N50 of 8.0 Mb. Identified repeat elements covered 34.65% of the genome, and 20,640 unique protein-coding genes with 39,526 transcripts were annotated.ConclusionsWe demonstrated that the PacBio long-read sequencing platform alone is sufficient to generate a comprehensive de novo assembled genome and transcriptome of an important bat species. These results will provide useful insights and act as a resource to expand our understanding of bat evolution, ecology, physiology, immunology, viral infection, and transmission dynamics.

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Diversity and Evolution of Viral Pathogen Community in Cave Nectar Bats (Eonycteris spelaea).

Project description:Bats are unique mammals, exhibit distinctive life history traits and have unique immunological approaches to suppression of viral diseases upon infection. High-throughput next-generation sequencing has been used in characterizing the virome of different bat species. The cave nectar bat, Eonycteris spelaea, has a broad geographical range across Southeast Asia, India and southern China, however, little is known about their involvement in virus transmission. Here we investigate the diversity and abundance of viral communities from a colony of Eonycteris spelaea residing in Singapore. Our results detected 47 and 22 different virus families from bat fecal and urine samples, respectively. Among these, we identify a large number of virus families including Adenoviridae, Flaviviridae, Reoviridae, Papillomaviridae, Paramyxoviridae, Parvoviridae, Picornaviridae, and Polyomaviridae. In most cases, viral sequences from Eonycteris spelaea are genetically related to a group of bat viruses from other bat genera (e.g., Eidolon, Miniopterus, Rhinolophus and Rousettus). The results of this study improve our knowledge of the host range, spread and evolution of several important viral pathogens. More significantly, our findings provide a baseline to study the temporal patterns of virus shedding and how they correlate with bat phenological trends.

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Project description:This SuperSeries is composed of the SubSeries listed below.

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