Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Brain Region-Specific Gene expression in Exercise for a Mouse Model of Parkinson's Disease

ABSTRACT: Brain Region-Specific Gene expression in Exercise for a Mouse Model of Parkinson's Disease

PROVIDER: PRJNA848217 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR19631208_1.fastq.gz	Fastqsanger.gz
	SRR19631208_2.fastq.gz	Fastqsanger.gz
	SRR19631209_1.fastq.gz	Fastqsanger.gz
	SRR19631209_2.fastq.gz	Fastqsanger.gz
	SRR19631210_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 96

Similar Datasets

Brain Region-Specific Gene expression in Exercise for a Mouse Model of Parkinson's Disease

Project description:Exercise plays an essential role in improving motor symptoms in Parkinson’s disease (PD), but the mechanism in the central nervous system remains obscure. We tested effects of 12-week treadmill exercise on a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD and observed a significant improvement in motor ability. Here we performed RNA-sequencing on 4 brain regions from control animals, MPTP-induced PD mice and MPTP-induced PD mice treated with exercise for 12 weeks.

2022-07-13 | GSE205907 | GEO

Transcriptional analysis of multiple brain regions in Parkinson's disease

Project description:Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms. This SuperSeries is composed of the following subset Series: GSE20168: Transcriptional analysis of prefrontal area 9 in Parkinson's disease GSE20291: Transcriptional analysis of putamen in Parkinson's disease GSE20292: Transcriptional analysis of whole substantia nigra in Parkinson's disease Refer to individual Series

2010-03-23 | E-GEOD-20295 | biostudies-arrayexpress

Multiplex three dimensional brain gene expression mapping in a mouse model of Parkinson's disease

Project description:Voxelation is a novel technology designed to produce high throughput, three-dimensional imaging of gene expression patterns in the brain. In these experiments, mouse brains were dissected into 40 voxels, or cubes, by cutting 10 serial coronal sections and transecting each coronal section into fourths. Using microarrays, the gene expression pattern of 9000 genes was acquired for both a normal and a pharmacological model of Parkinson's disease (PD) mouse brain. The mice used in these experiments were C57BL/6J males 10-24 weeks in age. Keywords = voxelation, 3-D gene expression, Parkinson's disease Keywords: other

2002-03-29 | GSE30 | GEO

Exploring transcriptome-wide changes in the brain-localized immune cells in a mouse model of Parkinson's Disease

Project description:In this study we identify the gene expression changes that occur in the brain-localized immune cells in a mouse model of Parkinson's Disease. A mouse model of Parkinson's Disease was created as previously described by stereotacticaly injecting an AAV-expressing the human A53T_mutated form of a-Synuclein into the Substantia Nigra of adult mice, while control mice were injected with empty vector (EV). These mice exhibit neurodegeneration in the Substantia Nigra and Parkinson-like behaviour phenotypes. Sixteen weeks after the injection, the Substantia Nigra and Srtiatum were micro-dissected and a Percoll gradient was used to enrich for the immune cells present in these tissues. The immune cells were also isolated from the Substantia Nigra and Striatum of same-age WT uninjected mice (WT). RNA was isolated from these cells and single-end 75nt high throughput sequencing were performed on libraries prepared from the RNA. We identified over 400 genes that were differentially expressed between control and Parkinson's mice with a log2 fold-change > |0.75|. These genes were enriched for terms related to immune activation such as: cytokine processing, leukocyte activation, and antigen presentation. The genes associated with these GO terms tended to be up-regulated in the Parkinson's mice suggesting that brain-localized immune cells are more activated in Parkinson's disease.

2021-11-01 | GSE148784 | GEO

Transcriptional analysis of multiple brain regions in Parkinson's disease

2010-03-12 | GSE20295 | GEO

Mitochondrial Stress-induced H4K12 Hyperacetylation Dysregulates Transcription in Parkinson's Disease

Project description:Bulk RNA-Seq of littermate controls and Parkinson's disease (PD) transgenic mice models (n=3) The goals of this study are to compare transcriptome profiling (RNA-Seq) in the specific brain region of littermate control and our PD transgenic mice model and look for differential expression genes of interest

2024-04-03 | GSE180408 | GEO

Brain transcriptomic analysis in Parkinson's disease patients stratified by Braak Lewy body stage / Sex differences in Parkinson's disease brain transcriptome

Project description:To investigate transcriptomic changes associated with Parkinson's disease development we compared frontal cortex gene expression across four Braak Lewy body stage groups. Additionally we investigated sex-specific gene expression differences in neuropathologically healthy donors and Parkinson's disease patients at Braak Lewy body stage 5. We investigated sex-specific gene expression differences in neuropathologically healthy donors and Parkinson's disease patients at Braak Lewy body stage 5.

2022-10-28 | GSE216281 | GEO

circRNAs in human brains of Parkinson's disease

Project description:total RNA sequencing of Parkinson's disease 3 regions of human brain

2020-06-26 | GSE133101 | GEO

Expression analysis of dissected GPi in Parkinson's disease

Project description:Genome-wide transcriptome analysis of expression changes in Globus Pallidus interna (GPi) from Parkinson's disease brain tissue versus control brain tissue.

2010-02-04 | GSE20146 | GEO

Expression analysis of laser-dissected SNpc neurons in Parkinson's disease

Project description:Genome-wide transcriptome analysis of expression changes in laser-dissected SNpc neurons from Parkinson's disease brain tissue versus control brain tissue. Post-mortem brain expression analysis performed in 10 PD brain samples and 8 control brain samples.

2010-02-22 | E-GEOD-20141 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data