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Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy (PBMC)

ABSTRACT: Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy (PBMC)

PROVIDER: PRJNA849421 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19661300.fastq.gz	Fastqsanger.gz
	SRR19661400.fastq.gz	Fastqsanger.gz
	SRR19661500.fastq.gz	Fastqsanger.gz
	SRR19661600.fastq.gz	Fastqsanger.gz
	SRR19661700.fastq.gz	Fastqsanger.gz

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Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy (PBMC)

Project description:The Gauging Response in Allergic Rhinitis to Sublingual and Subcutaneous Immunotherapy (GRASS) study was a randomized, double-blind, placebo-controlled trial of individuals with timothy grass allergy who received 2 years of placebo, subcutaneous (SCIT), or sublingual immunotherapy (SLIT) and were followed for a total of 3 years. Here we utilized longitudinal transcriptomic profiling of nasal brush and peripheral blood mononuclear cell (PBMC) samples after allergen provocation collected in the GRASS study to uncover airway and systemic expression pathways mediating responsiveness to immunotherapy.

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Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy (nasal)

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Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy (nasal)

Project description:Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy (nasal)

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Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy

Project description:Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy

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Effector cell signatures in peripheral blood after nasal allergen challenge: biomarkers of the allergic response

Project description:This study investigated temporal transcriptomic changes in response to nasal allergen challenge of titrated timothy grass pollen. This is an open single-center observational study conducted outside the pollen season. Twelve participants with seasonal allergic rhinitis underwent a control (diluent) challenge followed by nasal allergen challenge after an interval of 14 days. On each challenge day, nasal challenge with control or titrated timothy grass pollen (Aquagen, phleum pratense; ALK) was administered. Peripheral blood was collected before nasal challenge (baseline) and at 3, 6 and 24 hours following challenge. RNA was extracted from whole blood and CD4 cells for microarray experiment using Affymetrix Human Gene 1.0 ST arrays.

2013-01-16 | E-GEOD-43497 | biostudies-arrayexpress

Effector cell signatures in peripheral blood after nasal allergen challenge: biomarkers of the allergic response

Project description:This study investigated temporal transcriptomic changes in response to nasal allergen challenge of titrated timothy grass pollen.

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Lack of allergy to timothy grass pollen is not a passive phenomenon but associated with allergen specific modulation of immune reactivity

Project description:Timothy grass (TG) pollen is a common seasonal airborne allergen associated with symptoms ranging from mild rhinitis to severe asthma. The aim of this study was to characterize changes in TG-specific T cell responses as a function of seasonality. Peripheral blood mononuclear cells (PBMC) obtained either during the pollen season or out of season, from allergic individuals and non-allergic controls were stimulated either with TG extract or a pool of previously identified immunodominant antigenic regions. PBMC from in season allergic subjects exhibit higher IL-5 and IL-10 responses compared to out of season donors. In the case of non-allergic subjects, as expected we observed lower IL-5 responses and robust production of IFNγ compared to allergic individuals. Strikingly, non-atopic donors exhibited an opposing pattern with decreased immune reactivity in-season. The broad downregulation in non-allergic donors indicates that healthy individuals are not oblivious to allergen exposure but rather react with an active modulation of the responses following the antigenic stimulus provided during the pollen season. Transcriptomic analysis of allergen-specific T cells defined genes modulated in concomitance with allergen exposure and inhibition of responses in non-allergic donors. Magnitude and functionality of T-helper cell responses differ substantially for in season versus out of season in allergic and non-allergic subjects. The results indicate specific and opposing modulation of immune responses following the antigenic stimulation during the pollen season. This seasonal modulation reflects the enactment of specific molecular programs associated with health and allergic disease.

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A Randomized Clinical Trial to Study the Effects of Single Doses of Corticosteroid on Response to Nasal Allergen Challenge in Patients

Project description:We profiled genome-wide gene expression in nasal scrapes following grass pollen challenge and Prednisone treatment. It was a randomized, double-blind, placebo-controlled, three-period, cross-over trial to evaluate the effects of single oral doses of 10 mg and 25 mg of prednisone on inflammatory mediators measured in nasal exudates after nasal allergen challenge in susceptible individuals with allergic rhinitis. It examined the ability to quantify responses to allergen challenge and resolve dose responsive treatment effects of prednisone.

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Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy

Project description:This SuperSeries is composed of the SubSeries listed below.

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Expression data from patients that has received grass pollen sublingual immunotherapy treatment for two years.

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