Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dynamics of regulatory elements in the liver during ruminant evolution

ABSTRACT: Dynamics of regulatory elements in the liver during ruminant evolution

PROVIDER: PRJNA851837 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR19787563_1.fastq.gz	Fastqsanger.gz
	SRR19787563_2.fastq.gz	Fastqsanger.gz
	SRR19787564_1.fastq.gz	Fastqsanger.gz
	SRR19787564_2.fastq.gz	Fastqsanger.gz
	SRR19787565_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 52

Similar Datasets

Dynamics of regulatory elements in the liver during ruminant evolution

Project description:To investigate the evolutionary changes of regulatory elements in ruminants, we then performed regulatory elements profiling analysis using ChIP-seq datasets (H3K27ac and H3K4me3) of liver from three ruminants.

2022-09-15 | GSE206736 | GEO

Ruminant-specific retrotransposons shape regulatory evolution of bovine immunity

Project description:Ruminant-specific retrotransposons shape regulatory evolution of bovine immunity

| PRJNA767619 | ENA

Dynamic changes of gene expression in the liver during ruminant evolution

Project description:Dynamic changes of gene expression in the liver during ruminant evolution

| PRJNA849569 | ENA

Dynamics and Function of Distal Regulatory Elements during Neurogenesis and Neuroplasticity

Project description:Gene regulation in mammals involves a complex interplay between promoter and distal regulatory elements that function in concert to drive precise spatio-temporal gene expression programs. However, the dynamics of distal gene regulatory elements and its function in transcriptional reprogramming that underlies neurogenesis and neuronal activity remain largely unknown. Here we use a combinatorial analysis of genomewide datasets for chromatin accessibility (FAIRE-Seq) and enhancer mark H3K27ac to reveal a highly dynamic nature of chromatin accessibility during neurogenesis that gets restricted to certain genomic regions as neurons acquire a post-mitotic, terminally differentiated state. We further reveal that the distal open regions serve as target sites of distinct transcription factors that function in a stage-specific manner to contribute to the transcriptional program underlying neuronal commitment and maturation. A prolonged NMDA-driven neural activity results in epigenetic reprogramming at a large number of distal regulatory elements as well as dramatic reorganization of super-enhancers that in turn mediate critical transcriptional responses. Taken together, these findings reveal dynamics of distal regulatory landscape during neurogenesis and uncover novel regulatory elements that function in concert with epigenetic mechanisms and transcription factors to generate transcriptome underlying neuronal development and function. FAIRE-Seq and H3K27ac profiles for three stages on neuronal differentation viz. neuronal progenitors, day 1 neurons and day 10 neurons, were generated to understand the dynamics of accessible and ehancer chromatin landscape. Along with this we also generated RNASeq and H3K27ac profiles for day 10 neurons upon control and NMDA treatment.

2015-07-08 | E-GEOD-65713 | biostudies-arrayexpress

ruminant

Project description:ruminant Metagenomic assembly -RGMC

| PRJNA1190869 | ENA

ruminant genome project

Project description:Ruminant Genome Project

| PRJNA438286 | ENA

Gene silencing dynamics are modulated by transiently active regulatory elements

Project description:Gene silencing dynamics are modulated by transiently active regulatory elements

| PRJNA798037 | ENA

The prevalence, evolution and chromatin signatures of plant regulatory elements

Project description:The prevalence, evolution and chromatin signatures of plant regulatory elements