Klebsiella
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA852664 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:To investigate the role of outer membrane vesicles (OMVs) and related proteins in iron acquisition mechanism of hypervirulent Klebsiella pneumoniae (HVKP) and classic Klebsiella pneumoniae (cKP).
2021-08-21 | PXD028057 |
Project description:Elucidating the RamA Regulon in Klebsiella pneumoniae and the transcriptome profiles of multidrug resistant Klebsiella pneumoniae
2017-12-25 | GSE24688 | GEO
Project description:The evaluating the response of Bdellovibrio bacteriovorus HD100 with specific prey (Klebsiella pneumoniae)
2021-04-09 | GSE112863 | GEO
Project description:Klebsiella pneumoniae is an arising threat to human health. However, host immune responses in response to this bacterium remain to be elucidated. The goal of this study was to identify the dominant host immune responses associated with Klebsiella pneumoniae pulmonary infection. Pulmonary mRNA profiles of 6-8-weeks-old BALB/c mice infected with/without Klebsiella pneumoniae were generated by deep sequencing using Illumina Novaseq 6000. qRT–PCR validation was performed using SYBR Green assays. Using KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis, we identified several immune associated pathways, including complement and coagulation cascades, Toll-like receptor signaling pathway, Rap1 signaling pathway, chemokine signaling pathway, TNF signaling pathway, phagosome and NOD-like receptor signaling pathway, were involved in Klebsiella pneumoniae pulmonary infection. Using ICEPOP (Immune CEll POPulation) analysis, we found that several cell types were involved in the host immune response to Klebsiella pneumoniae pulmonary infection, including dendritic cells, macrophages, monocytes, NK (natural killer) cells, stromal cells. Further, IL-17 chemokines were significantly increased during Klebsiella pneumoniae infection. This study provided evidence for further studying the pathogenic mechanism of Klebsiella pneumoniae pneumonia infection.
2021-03-30 | GSE171048 | GEO
Project description:To investigate the whole-genome gene expression difference between the wild-type and capsule deletion mutant in Klebsiella pneumoniae MGH 78578. The mutants analyzed in this study are further described in Huang T.W., Stapleton J.C., Chang H.Y., Tsai S.F., Palsson B.O., Charusanti P. Capsule removal via lambda-Red knockout system perturbs biofilm formation and fimbriae extression in Klesiella pneumoniae MGH 78578 (manuscript submission) A six chip study using total RNA recovered from three separate wild-type cultures and three separate cultures of a capsule deltion mutant of Klebsiella pneumoniae MGH 78578. The capsule gene cluster (KPN_02493 to KPN_02515) was entirely removed in the capsule deletion mutant. Each chip measures the expression level of 5,305 genes from Klebsiella pneumoniae MGH 78578 and the associated five plasmids (pKPN3, pKPN4, pKPN5, pKPN6 and pKPN7) with 50-mer oligo tiling array with 30-mer spacer.
2013-12-31 | E-GEOD-40011 | biostudies-arrayexpress
Project description:This SuperSeries is composed of the following subset Series: GSE35746: Comparative analysis of regulatory elements between Escherichia coli and Klebsiella pneumoniae by genome-wide transcription start site profiling [tiling arrays] GSE35821: Comparative analysis of regulatory elements between Escherichia coli and Klebsiella pneumoniae by genome-wide transcription start site profiling [TSS-Seq] Refer to individual Series
2012-07-29 | E-GEOD-35822 | biostudies-arrayexpress
Project description:A strain of Klebsiella pneumoniae exposed to native and heat-inactivated serum for different time points
2023-10-16 | MSV000093124 | MassIVE
Project description:A strain of Klebsiella pneumoniae exposed to native and heat-inactivated serum for different time points
2023-10-16 | MSV000093124 | GNPS
Project description:The increasing antibiotic resistance of Klebsiella pneumoniae poses a serious threat to global public health. To investigate the antibiotic resistance mechanism of Klebsiella pneumonia, we performed gene expression profiling analysis using RNA-seq data for clinical isolates of Klebsiella pneumonia, KPN16 and ATCC13883. Our results showed that mutant strain KPN16 is likely to act against the antibiotics through increased increased butanoate metabolism and lipopolysaccharide biosynthesis, and decreased transmembrane transport activity.
2023-04-18 | GSE229867 | GEO
Project description:Klebsiella pneumoniae is a major pathogen that causes a variety of human infections, posing a significant public health threat. Understanding its pathogenesis is essential for devising effective treatment strategies. In this study, we aim to identify critical virulence factors in K. pneumoniae through analyzing virulence-associated genes that were identified in three transposon mutagenesis libraries. Two genes, wzi and kvrB, are consistently detected across these libraries, indicating their potential as critical virulence factors. While Wzi has usually been implicated in virulence through CPS, its actual function in K. pneumoniae pathogenicity has rarely been explored. Wzi deficiency reduces CPS production in K. pneumoniae, contrasting with its effect in Escherichia coli. Importantly, Wzi exerts a pivotal role in K. pneumoniae pathogenicity in vitro and in vivo, functioning through both CPS-dependent and -independent pathways. Wzi inhibits the secretion of IFN-γ-related cytokines at early infection stage to promote K. pneumoniae survival in the host. Wzi triggers sustained neutrophil recruitment during infection through the upregulation of CXCL1 expression, resulting in the pulmonary barrier damage and increased K. pneumoniae invasion into the bloodstream. Concurrently, Wzi confers K. pneumoniae to counteract neutrophil-mediated clearance in a CPS-dependent manner. Sequence polymorphisms of wzi significantly affect bacterial resistance to serum killing, with alleles frequently associated with hypervirulent K. pneumoniae exhibiting the highest resistance. Collectively, our findings highlight that the dual role of Wzi as a CPS-dependent and -independent virulence factor that combats host clearance during K. pneumoniae infection, representing a promising target for the development of anti-infective treatment against the bug.
2025-02-25 | GSE286873 | GEO