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ABSTRACT: WKY SHR IgA-SEQ

PROVIDER: PRJNA854082 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19898649_1.fastq.gz	Fastqsanger.gz
	SRR19898649_2.fastq.gz	Fastqsanger.gz
	SRR19898650_1.fastq.gz	Fastqsanger.gz
	SRR19898650_2.fastq.gz	Fastqsanger.gz
	SRR19898651_1.fastq.gz	Fastqsanger.gz

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Project description:SHR-WKY

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Potential Molecular Basis for Impaired Collateral Artery Growth in the Spontaneously Hypertensive Rat

Project description:Analysis of global gene expression in mesenteric control and collateral arteries was used to investigate potential molecules, pathways and mechanisms responsible for impaired collateral growth in the Spontaneously Hypertensive rat (SHR). A fundamental difference was observed in the overall gene expression pattern in SHR vs. Wistar Kyoto (WKY) collaterals (only 6% of the genes altered in collaterals were similar). IPA analysis identified major differences between WKY and SHR in networks and biological functions related to cell growth and proliferation and gene expression. Canonical pathways identified by IPA in WKY but not SHR included nitric oxide and renin angiotensin system signaling. The angiotensin type 1 receptor (AT1R) exhibited up-regulation in WKY collaterals, but down-regulation in SHR; pharmacological blockade of the AT1R with losartan prevented collateral luminal expansion in WKY. In SHR control arteries, several mechano-sensitive and redox-dependent transcription regulators were down-regulated including Jun (-5.2X, P=0.02), Egr-1 (-4.1X, P=0.01), and NFkB1 (-1.95X, P=0.04). Predicted binding sites for NFkB and AP-1 were present in the genes altered in WKY but not SHR collaterals. Immunostaining demonstrated increased NFkB nuclear translocation in WKY but not SHR collaterals, and in collaterals of SHR treated with apocynin to restore a normal redox status. Based upon these results, we propose redox-dependent modulation of mechano-sensitive transcription factors as a mechanism to explain, at least in part, the fundamental differences in collateral gene expression between WKY and SHR and the impairment of collateral growth during chronic oxidative stress. Key words: arteriogenesis, microarray analysis, peripheral vascular disease, gene expression

2010-12-15 | GSE19524 | GEO

Neferine treatment lower blood pressure in SHR

Project description:The goals of this study is to compare the differently expressed genes in abdominal aorta tissue of WKY and SHR as well as differently expressed genes in the abdominal aorta tissue of SHR with or without neferine treatment. The rat (n=15) were randomly divided into 3 groups: WKY,SHR, and SHR + neferine - H (high concentration) groups (n=6 for each group). Rat in WKY and SHR groups were intragastrically with double distilled water (dd H2O); while rat in SHR + SHR + neferine - H groups were intragastrically with 10mg/kg/D of neferine for 10 weeks. Then the abdominal aorta were used to identify differentially expressed genes among different groups.

2022-10-06 | GSE214655 | GEO

Gene expression profiles in the liver of spontaneously hypertensive rats at different stages of hypertension

Project description:The objective of this study was to characterize differences in the global gene expression profiles of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) at different stages of hypertension. Using RNA isolated from liver of SHR and WKY rats, we compared the gene expression profiles by microarrays. Differential gene expression was detected in the liver of SHR rats compared to WKY control rats, possibly contributing to hypertension

2017-03-15 | GSE96587 | GEO

Isoliensinine ameliorates renal injury via the TGF-β1/SMAD2/3 pathway in spontaneously hypertensive rats [kidney tissue]

Project description:The goals of this study is to compare the differently expressed genes in renal tissues of WKY and SHR with or without isoliensinine treatment. The SHRs (n=12) were randomly divided into 2 groups: SHR, and SHR + isoliensinine (5mg/kg/d) groups (n=6 for each group). WKY rats (n=6) were set as control. Rats in WKY and SHR groups were intragastrically with double distilled water (dd H2O); while rats in SHR + isoliensinine (5mg/kg/d) group were intragastrically with 5mg/kg/d of isoliensinine for 10 weeks. Then the renal tissues were used to identify differentially expressed genes among different groups.

2023-09-20 | GSE225146 | GEO

Ethoxysanguinarine ameliorates vascular remodeling by regulating TGF-β1/Smad2/3 signaling pathway in Hypertension：An in vitro and in vivo approach

Project description:The goals of this study is to compare the differently expressed genes in abdominal aortaof WKY and SHR with or without Ethoxysanguinarine (ETH) treatment. The SHRs (n=12) were randomly divided into 2 groups: SHR, and SHR +ETH (3.5mg/kg/d) groups (n=6 for each group). WKY rats (n=6) were set as control. Rats in WKY and SHR groups were intragastrically with double distilled water (dd H2O), while rats in SHR + ETH (3.5mg/kg/d) group were intragastrically with 3.5 mg/kg/d of ETH for 10 weeks. Then the vascular vessel tissues were used to identify differentially expressed genes among different groups.

2024-03-27 | GSE228356 | GEO

Small artery remodeling depends on the genetic background in spontaneously hypertensive rats (microRNA)

Project description:Spontaneously hypertensive rats (SHR) have been used frequently as a model for human essential hypertension. However, both the SHR and its normotensive control, the Wistar Kyoto rat (WKY), consist of genetically different sublines. We tested the hypothesis that discrepant data in literature regarding the pathophysiology of vascular remodeling in hypertension result from the use of different rat sublines. Using micro-arrays, we studied miRNA and mRNA expression in resistance arteries of WKY and SHR from three different sources, at 6 weeks and 5 months of age. Both WKY and SHR showed an age-related expression pattern that involved many genes related to the extracellular matrix. In SHR, this pattern was more extensive and included a specific increase in miR132-3p, and type III deiodinase. Direct comparison of WKY to SHR also yielded differences in expression, including thrombospondin 4. Heterogeneity in gene expression among sublines was associated with differences in blood pressure, body weight, vascular remodeling, endothelial function, and vessel ultrastructure. Common features in vessels from SHR were an increase in wall thickness, wall-to-lumen ratio, and internal elastic lamina thickness. These results indicate that endothelial dysfunction, vascular stiffening, and inward remodeling of small arteries are not common features of hypertension, but are subline-dependent. Relatively minor differences in genetic background associate with different types of vascular remodeling in hypertensive rats. The clinical implication of this study is that more research into personalized treatment in hypertension is warranted.

2015-10-02 | GSE53361 | GEO

RNA-seq of colonic epithelium of WKY and SHR

Project description:Alterations in genes between WKY and SHR epithelium

2019-05-04 | GSE130658 | GEO

RRBS of colonic epithelium of WKY and SHR

Project description:Alterations in DNA methylation between WKY and SHR epithelium

2019-05-04 | GSE130669 | GEO

Excessive leukotriene B4 in nucleus tractus solitarii is pro-hypertensive in spontaneously hypertensive rats.

Project description:We have used Affymetrix microarray-driven gene profiling to comprehensively describe the expression of mRNAs in the nucleus tractus solitarii (NTS) in the adult male spontaneously hypertensive rat (SHR) as compared to its normotensive parental Wistar-Kyoto (WKY) strain. Keywords: Gene expression NTS was dissected from hypertensive (SHR) and normotensive (WKY) strains of rat. For each structure, 10 independent Affymetrix Genechip 230 2.0 experiments were performed (5 SHR, 5 WKY), with each chip representing an independent biological replication (n=5).

2013-03-01 | E-GEOD-8796 | biostudies-arrayexpress

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