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Whole-transcriptome sequencing and ceRNA interaction network construction for temporomandibular joint osteoarthritis [miRNA-Seq]

ABSTRACT: Whole-transcriptome sequencing and ceRNA interaction network construction for temporomandibular joint osteoarthritis [miRNA-Seq]

PROVIDER: PRJNA855870 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19977503.fastq.gz	Fastqsanger.gz
	SRR19977504.fastq.gz	Fastqsanger.gz
	SRR19977505.fastq.gz	Fastqsanger.gz
	SRR19977506.fastq.gz	Fastqsanger.gz
	SRR19977507.fastq.gz	Fastqsanger.gz

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Whole-transcriptome sequencing and ceRNA interaction network construction for temporomandibular joint osteoarthritis [miRNA-Seq]

Project description:To investigate the functions of ncRNAs in temporomandibular joint osteoarthritis, we established temporomandibular joint osteoarthritis model induced by unilateral anterior crossbite. We then performed gene expression profiling analysis using data obtained from RNA-seq of condylar cartilage at 8 weeks of modeling.

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Whole-transcriptome sequencing and ceRNA interaction network construction for temporomandibular joint osteoarthritis [RNA-Seq]

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Whole-transcriptome sequencing and ceRNA interaction network construction for temporomandibular joint osteoarthritis [RNA-Seq]

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Project description:To investigate differentially expressed lncRNAs,circRNAs,miRNAs and mRNAs in synovium of human temporomandibular joint osteoarthritis (TMJOA), we performed RNA high-throughput sequencing in synovium of human TMJOA. We then performed gene expression profiling analysis using data obtained from RNA-seq .

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Project description:Temporomandibular joint osteoarthritis (TMJ-OA), a subtype of temporomandibular joint dysfunction (TMD), is characterized by progressive cartilage degradation, subchondral bone erosion, and chronic pain. Although there has been extensive research on TMJ-OA, its etiology remains unknown. Age, hormonal factors, and excessive mechanical stress on the TMJ are proposed risk factors for TMJ-OA. Using microarrays, we discovered two disease susceptibility genes that have been suggested to be involved in the pathogenic mechanism of TMJ-OA.

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