Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The immune landscape and mechanism of hepatitis B virus surface antigen clearance [RNA-Seq]

ABSTRACT: The immune landscape and mechanism of hepatitis B virus surface antigen clearance [RNA-Seq]

PROVIDER: PRJNA856138 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR19996151_1.fastq.gz	Fastqsanger.gz
	SRR19996151_2.fastq.gz	Fastqsanger.gz
	SRR19996152_1.fastq.gz	Fastqsanger.gz
	SRR19996152_2.fastq.gz	Fastqsanger.gz
	SRR19996153_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

The immune landscape and mechanism of hepatitis B virus surface antigen clearance [CITEseq]

Project description:Hepatitis B virus (HBV) surface antigen (HBsAg) clearance constitutes the hallmark of resolution of acute infection and is a therapeutic goal for functional cure of chronic hepatitis B. Here, we reveal the immunological landscape and mechanism of HBsAg clearance in mice. After acquiring nonopsonized HBsAg, B cells prime CD4+ T cell responses by CCR5- and EBI2-guided interaction with CD4+ T cells at follicular and interfollicular regions, respectively. Monocyte-derived macrophages transport complement-opsonized HBsAg to follicular dendritic cells (FDCs) to maintain germinal center reaction. Batf3+ XCR1+ conventional type 1 DCs (cDC1s) acquire and present HBsAg by MHC-I cross-dressing to drive CD8+ T cell responses in liver. We map the antigen-presenting cell (APC)-T cell crosstalk landscape and identify key costimulatory signals. The immune responses in patients with acute HBV infection are revealed by a single-cell transcriptome atlas. These findings revolutionize our understanding of anti-HBV immune responses and would lead to immunotherapeutic strategies for HBsAg clearance.

2024-07-01 | GSE207541 | GEO

The immune landscape and mechanism of hepatitis B virus surface antigen clearance [RNA-Seq]

2024-07-01 | GSE207539 | GEO

The immune landscape and mechanism of hepatitis B virus surface antigen clearance

Project description:The immune landscape and mechanism of hepatitis B virus surface antigen clearance

| PRJNA856130 | ENA

The immune landscape and mechanism of hepatitis B virus surface antigen clearance [CITEseq]

Project description:The immune landscape and mechanism of hepatitis B virus surface antigen clearance [CITEseq]

| PRJNA856137 | ENA

Study on the pathogenic mechanism of hepatitis B virus surface antigen

Project description:There are more than 240 million people worldwide chronically infected with HBV, among which, some may develop HBV-related cancer or end stage liver diseases. Lipid disorder remains one of the main mechanisms for chronic liver diseases. To explore the mechanisms induced by hepatitis B surface antigen in lipid disorder, a new pathway was revealed. These findings partially explained how SHBs could promote liver lipid disorder, and may provide a potential new intervention target in HBV related liver diseases.

2020-07-24 | PXD020569 |

The immune landscape and mechanism of hepatitis B virus surface antigen clearance

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-07-01 | GSE207543 | GEO

Transcriptomic profiling of antigen-specific T cells at the single-cell level after clearance of hepatitis C virus

Project description:We used scRNA-seq data generated using Smart-seq2 to reconstruct the native TCR from Ag-specific T cells and then to link these with the gene expression profile of individual cells. antigen specific CD8 T cells were obtained from a subject who had previously cleared hepatitis C virus (HCV) infection. A cell line was also generated from the same subject and included in the analysis with and without antigen stimulation.

2017-01-31 | E-MTAB-4850 | biostudies-arrayexpress

Transcriptomic profiling of antigen-specific T cells at the single-cell level after clearance of hepatitis C virus

Project description:Transcriptomic profiling of antigen-specific T cells at the single-cell level after clearance of hepatitis C virus

| PRJEB19013 | ENA

HCC prediction after clearance of HCV in chronic hepatitis C I

Project description:HCC prediction after clearance of HCV in chronic hepatitis C I

| PRJNA488275 | ENA

HCC prediction after clearance of HCV in chronic hepatitis C II

Project description:HCC prediction after clearance of HCV in chronic hepatitis C II

| PRJNA488280 | ENA