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A novel prognostic risk model for cervical cancer based on immune checkpoint HLA-G-driven differentially expressed genes [SiHa]

ABSTRACT: A novel prognostic risk model for cervical cancer based on immune checkpoint HLA-G-driven differentially expressed genes [SiHa]

PROVIDER: PRJNA858421 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR20140644.fastq.gz	Fastqsanger.gz
	SRR20140645.fastq.gz	Fastqsanger.gz
	SRR20140646.fastq.gz	Fastqsanger.gz
	SRR20140647.fastq.gz	Fastqsanger.gz
	SRR20140648.fastq.gz	Fastqsanger.gz

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A novel prognostic risk model for cervical cancer based on immune checkpoint HLA-G-driven differentially expressed genes [SiHa]

Project description:The aim of this study was to construct and validate a prognostic risk model to predict the overall survival (OS) of patients with cervical cancer, providing a reference for individualized clinical treatment that may lead to better clinical outcomes. HLA-G-driven DEG signature consisting of the eight most important prognostic genes CD46, LGALS9, PGM1, SPRY4, CACNB3, PLIN2, MSMO1, and DAGLB was identified as a key predictor of cervical cancer. To summarize, we developed and validated a novel prognostic risk model for cervical cancer based on HLA-G-driven DEGs, and the prognostic signature showed great ability in predicting the overall survival of patients with cervical cancer.

2022-07-19 | GSE208118 | GEO

A novel prognostic risk model for cervical cancer based on immune checkpoint HLA-G-driven differentially expressed genes [HeLa]

2022-07-19 | GSE208117 | GEO

RNA-Seq of H8, SiHa and KD HSPA9 SiHa cells

Project description:To investigate the different gens expression in the cervical immortalized cervical cells (H8 cells), cervical cancer cells (SiHa cells) and KD HSPA9 SiHa cells.

2023-06-25 | GSE235550 | GEO

A novel prognostic risk model for cervical cancer based on immune checkpoint HLA-G-driven differentially expressed genes

Project description:A novel prognostic risk model for cervical cancer based on immune checkpoint HLA-G-driven differentially expressed genes

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ChIP-Seq hnRNP E1, Cervical cancer SiHa cells

Project description:Based on the specificity with which the unique KH structural domains of hnRNP E1 bind with RNA/DNA, considering that HPV16 provides RNA/DNA binding sites, we hypothesized that hnRNP E1 may be crucial to HPV16 oncogenes expression and cervical carcinogenesis. Based on the main purpose of this study was to explore the role of hnRNP E1 on the regulation of HPV16 oncogene expression in cervical cancerization, we conducted ChIP-seq in the untreated SiHa cell line.

2022-06-16 | GSE203023 | GEO

miRNA expression profiles among SiHa, SiHa-tw2 and SiHa-shtw2

Project description:To further identify the most significantly changed miRNA resulting from the different expression levels of TWIST2 in cervical cancer cells, we used a miRNA microarray to identify the miRNA expression profiles among SiHa, SiHa-tw2 and SiHa-shtw2. The significantly deregulated miRNAs (changes of more than 2-fold in expression) included miR-23b-5p, miR-221-3p, miR-502-3p, miR-221-5p, miR-15a-5p, miR-1227, miR-93-5p and miR-4257.

2017-11-21 | GSE102706 | GEO

A novel prognostic risk model for cervical cancer based on immune checkpoint HLA-G-driven differentially expressed genes [HeLa]

Project description:A novel prognostic risk model for cervical cancer based on immune checkpoint HLA-G-driven differentially expressed genes [HeLa]

| PRJNA858423 | ENA

Transcriptome analysis of SiHa cells

Project description:This study assessed the transcriptional profile of SiHa cells. SiHa is a cervical cancer cell line with integrated HPV16, and was used as a model to study human gene expression in the context of integrated virus. Gene expression in SiHa, calculated by Cufflinks, was scored in windows around the locations of known viral integrations in patients or cell lines to determine if there was an association between gene expression and viral integration. We found that SiHa gene expression was higher near loci of integration for HPV18 vs. HPV16, cervical tissues vs. head and neck cancers, and cervical cancers vs. in vitro integrations. This study provides insight into the factors that may influence where viruses integrate in the human genome.

2015-11-30 | GSE67115 | GEO

Effects of SHetA2 on SiHa and C-33 A human cervical cancer cell lines

Project description:The objective was to identify how cervical cancer cells respond to treatment with the investigational new agent, Sulfur Heteroartoinoid A2 (SHetA2, NSC 726189) by identify proteins that are detected at significantly different levels in SHetA2-treated compared to untreated control cultures. Triplicate cultures of SiHa and C-33 A human cervical cancer cell lines were treated with 10 micromolar SHetA2 or the same volume of dimethylsulfoxide solvent (untreated controls) for 24 hours. Proteins were extracted from the cultures using M-PER (ThermoFisher).

2023-08-29 | PXD029537 | Pride

ChIP-Seq hnRNP E1, Cervical cancer SiHa cells

Project description:ChIP-Seq hnRNP E1, Cervical cancer SiHa cells

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