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Characterization of in vitro cultured alveolar macrophages (AM) transcriptomes following DON treatment

ABSTRACT: Characterization of in vitro cultured alveolar macrophages (AM) transcriptomes following DON treatment

PROVIDER: PRJNA863624 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR20710603_1.fastq.gz	Fastqsanger.gz
	SRR20710603_2.fastq.gz	Fastqsanger.gz
	SRR20710604_1.fastq.gz	Fastqsanger.gz
	SRR20710604_2.fastq.gz	Fastqsanger.gz
	SRR20710605_1.fastq.gz	Fastqsanger.gz

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Characterization of in vitro cultured alveolar macrophages (AM) transcriptomes following DON treatment

Project description:To identify molecular characteristics of WT AM with or without DON stimulation in vitro, we isolated RNA from AMs with various treatments and examined by bulk RNA-seq. We found a large number of gene profiles were altered following DON treatment in WT AMs, suggesting that DON treatment altered the balance of proliferative versus inflammatory genes in AMs, and glutamine metabolism is important in regulating AM self-renewal ability.

2023-12-31 | GSE210076 | GEO

Characterization of in vitro cultured alveolar macrophages (AM) transcriptomes

Project description:Characterization of in vitro cultured alveolar macrophages (AM) transcriptomes

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Characterization of in vitro cultured alveolar macrophages (AM) transcriptomes and heterogeneity following Wnt3a treatment

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Characterization of in vitro cultured alveolar macrophages (AM) transcriptomes [bulk RNA-seq]

Project description:Characterization of in vitro cultured alveolar macrophages (AM) transcriptomes [bulk RNA-seq]

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Characterization of in vitro cultured alveolar macrophages (AM) transcriptomes and heterogeneity following Wnt3a treatment

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-05-05 | GSE164793 | GEO

Characterization of in vitro cultured alveolar macrophages (AM) heterogeneity following Wnt3a treatment [single-cell RNA-seq]

Project description:Characterization of in vitro cultured alveolar macrophages (AM) heterogeneity following Wnt3a treatment [single-cell RNA-seq]

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Characterization of in vitro cultured alveolar macrophages (AM) transcriptomes

Project description:To identify molecular characteristics of mouse AMs stimulated with or without Poly(I:C) in the presence of vehicle or MSDC overnight in vitro, we isolated RNA from AMs with various treatments and examined by bulk RNA-seq. We found a large number of cytokine gene profiles were reduced following MSDC treatment in WT AMs, suggesting that MSDC treatment recuced inflammatory response in AMs.

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Comparative effect of DON and plant or microbial biotransformation of DON on gene expression of piglets jejunal explants

Project description:Deoxynivalenol (DON) is a frequent mycotoxin in grains, produced by Fusarium fungi, which demonstre multiple side effects such as modulation of immune responses, reduced feed intake and weight gain or impairment of the intestinal barrier function. Among animal species, pigs are the best model for humans and are very sensitive to DON. In wheat, DON can be conjugated to glucose to form DON-3-β-D-glucoside (D3G). Some bacteria isolated from digestive tracts or soil, are also able to de-epoxydize or epimerize DON to metabolites such as deepoxy-deoxynivalenol (DOM-1) or 3-epi-deoxynivalenol (epi-DON). The toxicity of these DON metabolites is poorly documented. By the way of ingestion, the intestine is the first organ exposed to these molecules and so constitute a relevant model. The aim of this study was to compare the intestinal toxicity of three DON metabolites (D3G, DOM-1 and epi-DON) with the one of DON. Intestinal explants from 6 pigs were treated with 10mM DON, D3G, DOM-1 or epi-DON for 4 hours and transcriptomic analysis was performed using an “Agilent Porcinet 60K”.

2016-07-20 | GSE66918 | GEO

Comparative effect of DON and plant or microbial biotransformation of DON on gene expression of piglets jejunal explants

Project description:Deoxynivalenol (DON) is a frequent mycotoxin in grains, produced by Fusarium fungi, which demonstre multiple side effects such as modulation of immune responses, reduced feed intake and weight gain or impairment of the intestinal barrier function. Among animal species, pigs are the best model for humans and are very sensitive to DON. In wheat, DON can be conjugated to glucose to form DON-3-Î²-D-glucoside (D3G). Some bacteria isolated from digestive tracts or soil, are also able to de-epoxydize or epimerize DON to metabolites such as deepoxy-deoxynivalenol (DOM-1) or 3-epi-deoxynivalenol (epi-DON). The toxicity of these DON metabolites is poorly documented. By the way of ingestion, the intestine is the first organ exposed to these molecules and so constitute a relevant model. The aim of this study was to compare the intestinal toxicity of three DON metabolites (D3G, DOM-1 and epi-DON) with the one of DON. Intestinal explants from 6 pigs were treated with 10mM DON, D3G, DOM-1 or epi-DON for 4 hours and transcriptomic analysis was performed using an âAgilent Porcinet 60Kâ. Jejunal explants from 4 piglets aged of 5 weeks were sampled and exposed in vitro to differents molecules (DON, D3G, DOM-1 & 3-epi-DON) at 10ÂµM during 4h. Then RNA was extracted.

2016-07-20 | E-GEOD-66918 | biostudies-arrayexpress

Transcriptome analysis of cultured human alveolar epithelial type 2 cells

Project description:We investigated whether in vitro expansion of human alveolar epithelial type II cells is possible. We found that human endogenous human alveolar epithelial type II cells can be cultured and passaged. The culture system enabled retroviral gene transduction into human alveolar epithelial type II cells. We performed RNA sequencing of human alveolar epithelial type II cells transduced with mutant surfactant protein C or control vector.

2019-06-27 | GSE128291 | GEO

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