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Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors

ABSTRACT: Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors

PROVIDER: PRJNA865269 | ENA |

REPOSITORIES: ENA

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Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors

Project description:Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors

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Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors

Project description:Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors

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Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors

Project description:Molecular profiling of childhood CNS tumors is critical for diagnosis and clinical management, yet tissue access is restricted due to the sensitive tumor location. We developed a targeted deep sequencing platform to detect tumor driver mutations, copy number variations, and heterogeneity in the liquid biome. Here, we present the sensitivity, specificity, and clinical relevance of our minimally invasive platform for tumor mutation profiling in children diagnosed with CNS cancer.

2022-08-03 | GSE210323 | GEO

Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer

Project description:RATIONALE: Radiolabeled monoclonal antibodies, such as iodine I 131 monoclonal antibody 3F8, can find tumor cells and carry tumor-killing substances to them without harming normal cells. This may be an effective treatment for central nervous system cancer or leptomeningeal metastases. PURPOSE: This phase II trial is studying the side effects and how well iodine I 131 monoclonal antibody 3F8 works in treating patients with central nervous system cancer or leptomeningeal cancer.

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Efavirenz Central Nervous System Side Effects

Project description:Efavirenz Central Nervous System Side Effects

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Tumor type and cell type-specific gene expression alterations in diverse pediatric central nervous system tumors identified using single nuclei RNA-seq

Project description:Central nervous system (CNS) tumors are the leading cause of pediatric cancer death, and these patients have an increased risk for developing secondary neoplasms. Due to the low prevalence of pediatric CNS tumors, major advances in targeted therapies have been lagging compared to other adult tumors. We collected single nuclei RNA-seq data from 35 pediatric CNS tumors and three non-tumoral pediatric brain tissues (84,700 nuclei) and characterized tumor heterogeneity and transcriptomic alterations. We distinguished cell subpopulations associated with specific tumor types including radial glial cells in ependymomas and oligodendrocyte precursor cells in astrocytomas. In tumors, we observed pathways important in neural stem cell-like populations, a cell type previously associated with therapy resistance. Lastly, we identified transcriptomic alterations among pediatric CNS tumor types compared to non-tumor tissues, while accounting for cell type effects on gene expression. Our results suggest potential tumor type and cell type-specific targets for pediatric CNS tumor treatment.

2023-08-08 | GSE211362 | GEO

Tumor type and cell type-specific gene expression alterations in diverse pediatric central nervous system tumors identified using single nuclei RNA-seq

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Deep sequencing of the locust Locusta migratoria manilensis central nervous system transcriptome

Project description:We report the application of single-molecule-based sequencing technology for high-throughput profiling of nervous system in locust Locusta migratoria manilensis. By obtaining over 57,000,000 bases of sequence from central nervous system, we generated 101836 contigs and 69440 scaffolds. We finally get 41179 unigene with an average length of 570bp. There are 5519 unigenes beyond the length of 1000bp. Using BLAST searches of the NR, NT, Swiss-Prot, KEGG and COG databases we are able to identify 13552 unigene (E<0.0001). Comprehensive assessment of all the unigenes by comparing with the studied genes of other insects nervous system reveals that our unigene are broadly representative of the transcriptome of insect nervous system. Our data provides the most large-scale EST-project for locust nervous system, which greatly benefits the exploring of this insect. In addition, we identify a large number of novel nervous genes which can be used in systematic studies of locust and other insects. Examination of 1 sample

2011-01-04 | E-GEOD-24498 | biostudies-arrayexpress

Array-based bioinformatic analysis on pediatric primary central nervous system germ cell tumors

Project description:This SuperSeries is composed of the following subset Series: GSE19347: microRNA expression data from pediatric primary intracranial germ cell tumor GSE19348: expression data from pediatric primary intracranial germ cell tumor GSE19349: Genotyping and analysis of chromosome copy number variation (CNV) from pediatric primary intracranial germ cell tumor Refer to individual Series

2010-06-24 | E-GEOD-19350 | biostudies-arrayexpress

Genomic profiling combined with gene expression profiling in primary central nervous system lymphoma

Project description:This SuperSeries is composed of the following subset Series: GSE25297: Genome-wide gene expression comparison (primary central nervous system lymphoma (PCNSL) vs normal lymph node) GSE25298: Genomic aberrations in primary central nervous system lymphoma (PCNSL) Refer to individual Series

2010-11-13 | E-GEOD-25299 | biostudies-arrayexpress

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