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Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors

ABSTRACT: Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors

PROVIDER: PRJNA869171 | ENA |

REPOSITORIES: ENA

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Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors

Project description:Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors

| PRJNA869170 | ENA

Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors

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Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors.

Project description:Molecular profiling of childhood CNS tumors is critical for diagnosis and clinical management, yet tissue access is restricted due to the sensitive tumor location. We developed a targeted deep sequencing platform to detect tumor driver mutations, copy number variations, and heterogeneity in the liquid biome. Here, we present the sensitivity, specificity, and clinical relevance of our minimally invasive platform for tumor mutation profiling in children diagnosed with CNS cancer.

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Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors

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Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer

Project description:RATIONALE: Radiolabeled monoclonal antibodies, such as iodine I 131 monoclonal antibody 3F8, can find tumor cells and carry tumor-killing substances to them without harming normal cells. This may be an effective treatment for central nervous system cancer or leptomeningeal metastases. PURPOSE: This phase II trial is studying the side effects and how well iodine I 131 monoclonal antibody 3F8 works in treating patients with central nervous system cancer or leptomeningeal cancer.

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