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Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [scRNA-seq]

ABSTRACT: Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [scRNA-seq]

PROVIDER: PRJNA868764 | ENA |

REPOSITORIES: ENA

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Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors

Project description:Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors

| PRJNA869105 | ENA

Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [scATAC-seq]

Project description:Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [scATAC-seq]

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Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [bulk RNA-seq]

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Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [bulk ATAC-seq]

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Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [mouse bulk ATAC-seq]

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Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [scRNA-seq]

Project description:Regulatory T (Treg) cells suppress effective antitumor immunity in tumor-bearing hosts, thereby becoming promising targets in cancer immunotherapy. Here, we show that Treg cells in the tumor microenvironment (TME) of human lung cancers harbor a completely different open chromatin profile compared to effector T cells and peripheral Treg cells. The integrative sequencing analyses revealed that BATF, IRF4, NF-κb, and NR4A were important transcription factors for Treg cell differentiation in the TME. Particularly, BATF was identified as a key regulator, which leveraged Treg cell differentiation through epigenetically controlling activation-associated gene expression, resulting in the robustness of Treg cells in the TME. BATF deficiency in Treg cells remarkably inhibited tumor growth and high BATF expression was associated with poor prognosis in lung cancer, kidney cancer, and melanoma. Our results propose the specific chromatin remodeling and differentiation program of Treg cells in the TME, which can be applied in the development of Treg cell-targeted therapies.

2022-08-22 | GSE211068 | GEO

Windows Scanning Multiomics: Integrated Metabolomics and Proteomics (Metabolomics Section)

Project description:To gain comprehensive and accurate system biological information, we developed a multiomics analytical method that integrated metabolomics and proteomics, named Windows Scanning Multiomics (WSM).

2023-12-18 | PXD046533 | Pride

Windows Scanning Multiomics: Integrated Metabolomics and Proteomics (Proteomics Section)

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Integrated multiomics (scATACseq and scRNAseq) of 2D10 cells treated with small molecules for 24hrs

Project description:Integrated multiomics (scATACseq and scRNAseq) of 2D10 cells treated with small molecules for 24hrs.

2023-12-30 | GSE210146 | GEO

Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology [scRNA-seq]

Project description:Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology [scRNA-seq]

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