Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors

ABSTRACT: Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors

PROVIDER: PRJNA869105 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR21029600.fastq.gz	Fastqsanger.gz
	SRR21029601.fastq.gz	Fastqsanger.gz
	SRR21019902_1.fastq.gz	Fastqsanger.gz
	SRR21019902_2.fastq.gz	Fastqsanger.gz
	SRR21029602.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 138

Similar Datasets

Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [scATAC-seq]

Project description:Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [scATAC-seq]

| PRJNA868789 | ENA

Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [scRNA-seq]

Project description:Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [scRNA-seq]

| PRJNA868764 | ENA

Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [bulk RNA-seq]

Project description:Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [bulk RNA-seq]

| PRJNA868732 | ENA

Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [bulk ATAC-seq]

Project description:Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [bulk ATAC-seq]

| PRJNA869108 | ENA

Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [mouse bulk ATAC-seq]

Project description:Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [mouse bulk ATAC-seq]

| PRJNA868754 | ENA

Windows Scanning Multiomics: Integrated Metabolomics and Proteomics (Proteomics Section)

Project description:To gain comprehensive and accurate system biological information, we developed a multiomics analytical method that integrated metabolomics and proteomics, named Windows Scanning Multiomics (WSM).

2023-12-18 | PXD046554 | Pride

Windows Scanning Multiomics: Integrated Metabolomics and Proteomics (Metabolomics Section)

2023-12-18 | PXD046533 | Pride

Integrated multiomics (scATACseq and scRNAseq) of 2D10 cells treated with small molecules for 24hrs

Project description:Integrated multiomics (scATACseq and scRNAseq) of 2D10 cells treated with small molecules for 24hrs.

2023-12-30 | GSE210146 | GEO

Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [scRNA-seq]

Project description:Regulatory T (Treg) cells suppress effective antitumor immunity in tumor-bearing hosts, thereby becoming promising targets in cancer immunotherapy. Here, we show that Treg cells in the tumor microenvironment (TME) of human lung cancers harbor a completely different open chromatin profile compared to effector T cells and peripheral Treg cells. The integrative sequencing analyses revealed that BATF, IRF4, NF-κb, and NR4A were important transcription factors for Treg cell differentiation in the TME. Particularly, BATF was identified as a key regulator, which leveraged Treg cell differentiation through epigenetically controlling activation-associated gene expression, resulting in the robustness of Treg cells in the TME. BATF deficiency in Treg cells remarkably inhibited tumor growth and high BATF expression was associated with poor prognosis in lung cancer, kidney cancer, and melanoma. Our results propose the specific chromatin remodeling and differentiation program of Treg cells in the TME, which can be applied in the development of Treg cell-targeted therapies.

2022-08-22 | GSE211068 | GEO

Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors [scATAC-seq]

2022-08-22 | GSE211087 | GEO