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Transcriptome data of bone marrow regulatory T cells (Tregs) with premature aging

ABSTRACT: Transcriptome data of bone marrow regulatory T cells (Tregs) with premature aging

PROVIDER: PRJNA869076 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21659715_1.fastq.gz	Fastqsanger.gz
	SRR21659715_2.fastq.gz	Fastqsanger.gz
	SRR21659716_1.fastq.gz	Fastqsanger.gz
	SRR21659716_2.fastq.gz	Fastqsanger.gz
	SRR21659717_1.fastq.gz	Fastqsanger.gz

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Transcriptome data of bone marrow regulatory T cells (Tregs) with premature aging

Project description:Bone marrow (BM) is normally maintained in an immune-privileged and anti-inflammatory state, kept in check principally by regulatory T cells (Tregs). Thus, it is reasonable to expect that Tregs will help shield hematopoietic stem cells (HSCs) from excessive inflammation and thereby counteract HSC aging. Understanding how BM Tregs are adapted to the aged BM and whether they are endowed with unique functions to modulate HSC aging will identify targets for prevention of HSC aging. To identify the phenotype switching and function variation in BM Tregs with physiological and premature aging, we performed RNA-seq of Tregs from the bone marrow of mice at three months post irradiation (IR) and their age-matched control mice (Ctrl).

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Transcriptome data of bone marrow hematopoietic stem cells (HSCs) with premature aging

Project description:Transcriptome data of bone marrow hematopoietic stem cells (HSCs) with premature aging

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